One of the reasons why it’s so hard to develop treatments for problems in the brain – things like Alzheimer’s, autism and schizophrenia - is that you can’t do an autopsy of a living brain to see what’s going wrong. People tend to object. To get around that, scientists have used stem cells to create … Continue reading Building a better brain organoid
organoids
Stem Cell Roundup: Backup cells to repair damaged lungs; your unique bowels; and California Cures, 71 ways CIRM is changing the face of medicine
It’s good to have a backup plan Our lungs are amazing things. They take in the air we breathe and move it into our blood so that oxygen can be carried to every part of our body. They’re also surprisingly large. If you were to spread out a lung – and I have no idea … Continue reading Stem Cell Roundup: Backup cells to repair damaged lungs; your unique bowels; and California Cures, 71 ways CIRM is changing the face of medicine
UC Davis researchers make stem cell-derived mini-brains that contain blood vessels
Growing neurons on a flat petri dish is a great way to study the inner workings of nerve signals in the brain. But I think it's safe to argue that a two-dimensional lawn of cells doesn’t capture all the complexity of our intricate, cauliflower-shaped brains. Then again, cracking open the skulls of living patients is … Continue reading UC Davis researchers make stem cell-derived mini-brains that contain blood vessels
Modeling the Human Brain in 3D
Can you guess what the tiny white balls are in this photo? I’ll give you a hint, they represent the organ that you’re using right now to answer my question. These are 3D brain organoids generated from human pluripotent stem cells growing in a culture dish. You can think of them as miniature models of … Continue reading Modeling the Human Brain in 3D
Stem cell-derived mini-intestines reveal bacteria’s key role in building up a newborn’s gut
The following factoid may induce an identity crisis for some people but it is true that our bodies carry more microbes than human cells. Some studies in 1970’s estimated the ratio at 10:1 though more recent calculations suggest we’re merely half microbe, half human. Because microbes are much smaller than human cells they make up … Continue reading Stem cell-derived mini-intestines reveal bacteria’s key role in building up a newborn’s gut
Stem cell stories that caught our eye: brains, brains and more brains!
This week we bring you three separate stories about the brain. Two are exciting new advances that use stem cells to understand the brain and the third is plain creepy. Bioengineering better brains. Lab grown mini-brains got an upgrade thanks to a study published this week in Nature Biotechnology. Mini-brains are tiny 3D organs that … Continue reading Stem cell stories that caught our eye: brains, brains and more brains!
One scientist’s quest to understand autism using stem cells
April is National Autism Awareness Month and people and organizations around the world are raising awareness about a disorder that affects more than 20 million people globally. Autism affects early brain development and causes a wide spectrum of social, mental, physical and emotional symptoms that appear during childhood. Because the symptoms and their severity can … Continue reading One scientist’s quest to understand autism using stem cells
Brain Models Get an Upgrade: 3D Mini-Brains
Every year, companies like Apple, Microsoft and Google work tirelessly to upgrade their computer, software and smartphone technologies to satisfy growing demands for more functionality. Much like these companies, biomedical scientists work tirelessly to improve the research techniques and models they use to understand and treat human disease. Today, I’ll be talking about a cool … Continue reading Brain Models Get an Upgrade: 3D Mini-Brains
UCSF Scientists find molecular link between brain stem cells and Zika Infection
The Zika virus scare came to a head in 2015, prompting the World Health Organization to declare the outbreak a global health emergency earlier this year. From a research standpoint, much of the effort has centered on understanding whether the Zika infection is actually a cause of birth defects like microcephaly and how the virus … Continue reading UCSF Scientists find molecular link between brain stem cells and Zika Infection
Scientists use cotton candy to make artificial blood vessels
Cotton candy gets a bad rap. The irresistible, brightly colored cloud of sugar is notorious for sending kids into hyperactive overdrive and wreaking havoc on teeth. While it’s most typically found at a state fair or at a sports stadium, cotton candy is now popping up at the lab bench and is re-branding itself into … Continue reading Scientists use cotton candy to make artificial blood vessels
The Stem Cellar 