Dr. Alysson Muotri: Photo courtesy UC San Diego It's always gratifying when one of the projects you have funded starts to show promising results. It says your faith in the research and the researcher were well founded. But it's also fun when the project you fund turns up some really cool findings and is picked … Continue reading Brain wave of an idea is picked as one of the top science stories of the year
organoids
“Brains” in a dish that can create electrical impulses
Brain organoids in a petri dish: photo courtesy UCSD For several years, researchers have been able to take stem cells and use them to make three dimensional structures called organoids. These are a kind of mini organ that scientists can then use to study what happens in the real thing. For example, creating kidney organoids … Continue reading “Brains” in a dish that can create electrical impulses
Blood-brain barrier chip created with stem cells expands potential for personalized medicine
An Organ-Chip used in the study to create a blood-brain barrier (BBB). The brain is a complex part of the human body that allows for the formation of thoughts and consciousness. In many ways it is the essence of who we are as individuals. Because of its importance, our bodies have developed various layers of … Continue reading Blood-brain barrier chip created with stem cells expands potential for personalized medicine
3D brain model shows potential for treatment of hypoxic brain injuries in infants
Image of 3D brain cultures in the Sergiu Pasca lab. Photo courtesy of Timothy Archibald. Another study reported in Nature’s Scientific Reports showed progress in treating avulsion injuries, which damage nerve signals entering or leaving the spinal cord. These injuries often follow traffic, especially motorcycle, accidents and can cause paralysis, loss of sensation, and chronic … Continue reading 3D brain model shows potential for treatment of hypoxic brain injuries in infants
Organoids revolutionize approach to studying a variety of diseases
Organoids Microscopes limit how well we can study cells. To understand complex processes, we must observe cells in conditions that mimic the body. Organoids have transformed this research. Organoids and "mini-brains" Organoids are three‑dimensional structures grown from stem cells that mimic real organs. Recent studies have used this method to explore a wide range of … Continue reading Organoids revolutionize approach to studying a variety of diseases
Stem Cells make the cover of National Geographic
National Geographic is one of those iconic magazines that everyone knows about but few people read. Which is a shame, because it's been around since 1888 and has helped make generations of readers aware about the world around them. And now, it's shifting gears and helping people know more about the world inside them. That's … Continue reading Stem Cells make the cover of National Geographic
Stem Cell Roundup: The brain & obesity; iPSCs & sex chromosomes; modeling mental illness
Stem Cell Image of the Week: Obesity-in-a-dish reveals mutations and abnormal function in nerve cells Our stem cell image of the week looks like the work of a pre-historic cave dweller who got their hands on some DayGlo paint. But, in fact, it’s a fluorescence microscopy image of stem cell-derived brain cells from the lab … Continue reading Stem Cell Roundup: The brain & obesity; iPSCs & sex chromosomes; modeling mental illness
Building a better brain organoid
One of the reasons why it’s so hard to develop treatments for problems in the brain – things like Alzheimer’s, autism and schizophrenia - is that you can’t do an autopsy of a living brain to see what’s going wrong. People tend to object. To get around that, scientists have used stem cells to create … Continue reading Building a better brain organoid
Stem Cell Roundup: Backup cells to repair damaged lungs; your unique bowels; and California Cures, 71 ways CIRM is changing the face of medicine
It’s good to have a backup plan Our lungs are amazing things. They take in the air we breathe and move it into our blood so that oxygen can be carried to every part of our body. They’re also surprisingly large. If you were to spread out a lung – and I have no idea … Continue reading Stem Cell Roundup: Backup cells to repair damaged lungs; your unique bowels; and California Cures, 71 ways CIRM is changing the face of medicine
UC Davis researchers make stem cell-derived mini-brains that contain blood vessels
Growing neurons on a flat petri dish is a great way to study the inner workings of nerve signals in the brain. But I think it's safe to argue that a two-dimensional lawn of cells doesn’t capture all the complexity of our intricate, cauliflower-shaped brains. Then again, cracking open the skulls of living patients is … Continue reading UC Davis researchers make stem cell-derived mini-brains that contain blood vessels