Photo Courtesy of Andrea Fernandez de Soto Imagine stepping outside and facing life‑threatening danger. For children born with ADA‑SCID (adenosine deaminase severe combined immunodeficiency), this is daily life. Their immune systems are so weak that a cold or a scraped knee can cause a dangerous infection. Donald Kohn, MD, a leading researcher at the UCLA … Continue reading Potential Gene Therapy for Children with ADA-SCID
Stem cells
Transformative stem cell-based treatment for Cystic Fibrosis Sinusitis
A $6 million grant to Dr. Matthew Porteus and his team at Stanford University to develop an innovative stem cell-based gene correction therapy for chronic sinusitis in Cystic Fibrosis (CF) patients. CF is a common genetic disease that currently lacks a cure, causing patients to spend their lives managing symptoms. Despite significant advancements in CF … Continue reading Transformative stem cell-based treatment for Cystic Fibrosis Sinusitis
CIRM’s $31 million boost for cancer and eye disease research
The California Institute for Regenerative Medicine (CIRM) recently approved nearly $31 million in funding, further cementing our commitment to advancing the field of regenerative medicine. This substantial investment aims to drive clinical research targeting various cancers and eye diseases. CIRM’s dedication to fostering innovative treatments is demonstrated through its clinical program, which funds eligible stem … Continue reading CIRM’s $31 million boost for cancer and eye disease research
Investing in stem cell and gene therapy treatments for HIV
A recent article in Nature shared the news about a 53-year-old man in Germany who was declared free of HIV after receiving virus-resistant cells. The man—referred to as the “Düsseldorf patient”—was diagnosed with acute myeloid leukemia and underwent a stem cell transplant in 2013 that replaced his bone marrow cells with HIV-resistant stem cells from … Continue reading Investing in stem cell and gene therapy treatments for HIV
CIRM funds clinical trial to make cancer therapy safer, less toxic
Blood stem cell transplantation following high dose chemotherapy is standard of care and potentially curative for aggressive forms of lymphoma. However, this treatment regimen is limited by severe toxicity and life-threatening complications due to delayed recovery of the blood system and vascular related damage of multiple organs. Today the governing Board of the California Institute … Continue reading CIRM funds clinical trial to make cancer therapy safer, less toxic
CIRM-funding supports world’s first stem cell treatment for spina bifida delivered during fetal surgery
Dr. Diana Farmer (right) meets with Emily Lofton and her baby Robbie who had stem cell treatment for spina bifida in the womb. Photo: UC Davis Health The California Institute for Regenerative Medicine (CIRM) recently shared some encouraging news on The Stem Cellar about a CIRM-funded stem cell clinical trial for spina bifida at UC … Continue reading CIRM-funding supports world’s first stem cell treatment for spina bifida delivered during fetal surgery
CIRM-funded stem cell-gene therapy shows promise in ALS safety trial
Senior author of the study Clive Svendsen, PhD (center) With funding support from the California Institute for Regenerative Medicine (CIRM), Cedars-Sinai investigators have developed an investigational therapy using support cells and a protective protein that can be delivered past the blood-brain barrier. This combined stem cell and gene therapy can potentially protect diseased motor neurons … Continue reading CIRM-funded stem cell-gene therapy shows promise in ALS safety trial
How this scientist uses Legos to explain the power of stem cells
Explaining science is hard. Explaining stem cells, which have their very own unique complexities, can be even more of a challenge, especially when communicating with a non-scientific audience. That’s why when we received this blog submission from a CIRM SPARK Program intern through UCSF’s High School Intern Program (HIP) explaining stem cells in a simple, … Continue reading How this scientist uses Legos to explain the power of stem cells
Stem cells explained in different languages
Science is hard. Explaining complex science to non-scientists is SUPER hard. But explaining science to non-native English speakers presents a whole new set of challenges. I would know. I’m a first-generation immigrant whose highly-educated parents arrived in their new home—the United States—a tad too late to become fluent in its native tongue. I’ve also … Continue reading Stem cells explained in different languages
Study shows sleep deprivation impairs stem cells in the cornea
We spend around one third of our life sleeping—or at least we should. Not getting enough sleep can have serious consequences on many aspects of our health and has been linked to high blood pressure, heart disease and stroke. A study by the American Sleep Apnea Association found that some 70 percent of Americans report getting … Continue reading Study shows sleep deprivation impairs stem cells in the cornea