By: Dr. Kelly Shepard, Associate Director, Discovery and Translation, CIRM
Every July, CIRM is thrilled to announce the arrival a new generation of stem cell scientists who are ready to hit the ground running as laboratory technicians, educators, communicators, or future leaders of their chosen profession. These diverse and remarkable individuals are the latest graduates of the CIRM Bridges Program, which provides students the opportunity to take coursework at California state schools and community colleges and conduct stem cell research at top universities and industry labs. The culmination of this experience is an annual conference where students are able to network with their peers and share their research outcomes with one another.
While the Bridges program has been operating in full force for 11 years now, 2020 brought some new challenges to everyone in the form of a global pandemic. Shelter in place orders- cancellation of in person classes- travel restrictions…. these are only a few of the factors that have touched our lives in recent months. But sometimes challenges bring opportunities and a new way of doing things. Through the collective efforts of program directors, institutional officials, mentors and students, the 2020 Bridges alumni were able to complete their training requirements at their institutions and present their research at the Annual Bridges Conference, which was conducted virtually this year. While visiting students posters via Zoom, we at CIRM were thrilled to learn that many of them already had jobs waiting for them or had been accepted into PhD or MD programs, similar to alumni from previous years, which now number over 1400.
While we cannot predict all of the twists and turns that life may bring us, we can be confident that scientific research and discovery will remain essential to creating a brighter future, and that Bridges alumni will be there to help us navigate it.
It’s been a long time coming. Eighteen months to be precise. Which is a peculiarly long time for an Annual Report. The world is certainly a very different place today than when we started, and yet our core mission hasn’t changed at all, except to spring into action to make our own contribution to fighting the coronavirus.
This latest CIRM Annual Reportcovers 2019 through June 30, 2020. Why? Well, as you probably know we are running out of money and could be funding our last new awards by the end of this year. So, we wanted to produce as complete a picture of our achievements as we could – keeping in mind that we might not be around to produce a report next year.
It’s a pretty jam-packed report. It covers everything from the 14 new clinical trials we have funded this year, including three specifically focused on COVID-19. It looks at the extraordinary researchers that we fund and the progress they have made, and the billions of additional dollars our funding has helped leverage for California. But at the heart of it, and at the heart of everything we do, are the patients. They’re the reason we are here. They are the reason we do what we do.
There are stories of people like Byron Jenkins who almost died from multiple myeloma but is now back leading a full, active life with his family thanks to a CIRM-funded therapy with Poseida. There is Jordan Janz, a young man who once depended on taking 56 pills a day to keep his rare disease, cystinosis, under control but is now hoping a stem cell therapy developed by Dr. Stephanie Cherqui and her team at UC San Diego will make that something of the past.
These individuals are remarkable on so many levels, not the least because they were willing to be among the first people ever to try these therapies. They are pioneers in every sense of the word.
There is a lot of information in the report, charting the work we have done over the last 18 months. But it’s also a celebration of everyone who made it possible, and our way of saying thank you to the people of California who gave us this incredible honor and opportunity to do this work.
At CIRM we don’t just invest in stem cell research, we invest in people. One prime example of that is our Bridges to Stem Cell Research program. This is helping train the next generation of scientists by preparing Californian undergraduate and master’s students for careers in stem cell research.
The students who go through the Bridges program get up to a year-long internship, hands-on training and education in stem cell research. Just as importantly, they also get to work directly with patients to help them understand why we do this work; to help people in need.
One of our recent
Bridges graduates is Zach Wagoner. Zach was a biology student and wondering what
to do next to help him get some experience for a job when someone told him
about the Bridges program. That set him on a course that is changing his life.
So how did the random conversation impact Zach? The team at the UC Irvine Sue and Bill Gross Stem Cell Research Center shot this video to answer that question.
It’s not just Zach who benefited from the program. Of the 1257 alumni who graduated from the program by March of this year:
50% are working full time in academic or
biotech research related positions
When Californians voted for Proposition 71 in 2004, they were investing in hope… the hope that unraveling the mysteries of stem cells could lead to new types of treatments and perhaps one day, even cures for some of the most devastating illnesses and injuries known to mankind. Making this hope a reality, however, requires much more than scientific discovery, it requires a dedicated and skilled work force that can recognize and tackle the challenges that come with such an ambitious dream.
To jump start the nascent stem cell/regenerative medicine community in California, CIRM began offering Training Grants to major research and medical institutions to attract talented PhD students and postdoctoral fellows into the field. A few years later, a second type of training program was born to attract a different, yet equally important cadre of professionals – the undergraduate, Bachelors and Master’s level scientists who are the bread and butter of any successful research endeavor.
Over the past 10 years, CIRM has supported 16 of these programs, which have proven to be among the most popular and successful CIRM initiatives to date. As of 2019, the Bridges programs have trained well over 1400 scientists, about half of whom are working full time in research positions at biotechnology companies or academic laboratories, and another third of whom are currently enrolled in a graduate or professional school.
Today, there are 14 active Bridges Programs around the state, each with unique attributes, but all sharing the core elements of stem cell-based coursework, hands-on-training through internships at world-class laboratories or biotechnology companies, and formal activities involving patient engagement and community outreach. Every year, the programs produce up to 140 well-rounded, highly skilled individuals that are ready to hit the ground running.
the most recent cohort of Bridges trainees gather for an Annual Conference to
share their research outcomes, network with their peers, and learn more about
the current opportunities and challenges facing the regenerative medicine
This year, the 10th Annual Bridges Conference was held in San Mateo, CA and included inspiring talks from scientists performing cutting edge research and running some of the first FDA-approved stem-cell based clinical trials in the state.
Perhaps the biggest highlights were hearing the real-life stories of brave individuals like Anna Simos, whose experience with life-threatening complications from diabetes inspired her life’s work of providing hope and education to those facing similar challenges.
Equally moving was the testimonial of Byron Jenkins, a multiple myeloma patient who received an experimental new CAR-T therapy in a CIRM-supported clinical trial sponsored by Poseida Therapeutics.
Last but not least, little Ronnie Kashyup, recently cured of Bubble Baby Disease through another CIRM-funded clinical trial, charmed all attendees with his larger-than-life personality while his father, Pawash Priyank, shared the story of Ronnie’s diagnosis and treatment.
In the video segments to follow:
CIRM Bridges student Sneha Santosh at San Jose State University discusses the role CIRM plays in bridging together the patient advocates with the groundbreaking research conducted by scientists.
Samori Dobson and Esther Nair, CIRM Bridges students at California State University, San Marcos, briefly discuss the positive impact that the program has had on their lives.
Below are some pictures form the 10th Annual Bridges Conference in San Mateo, CA.
For more information about CIRM Bridges Programs, see the following link and video below:
Students present their research finding at the 2016 CIRM Bridges conference
One of the programs people here at CIRM love is our Bridges to Stem Cell Research Awards. These are given to undergraduate and master’s level college students, to train the next generation of stem cell scientists. How good a program is it? It’s terrific. You don’t have to take my word for it. Just read this piece by a great stem cell champion, Don Reed. Don is the author of two books about CIRM, Stem Cell Battles and California Cures! so he clearly knows what he’s talking about.
ADVENTURES ON “BRIDGES”: Humboldt State Stem Cell Research
By Don C. Reed
Imagine yourself as a California college student, hoping to become a stem cell researcher. Like almost all students you are in need of financial help, and so (let’s say) you asked your college counselor if there were any scholarships available.
To your delight, she said, well, there is this wonderful internship program called Bridges, funded by the California Institution for Regenerative Medicine (CIRM) which funds training in stem cell biology and regenerative medicine — and so, naturally, you applied…
After doing some basic training at the college, you would receive a grant (roughly $40,000) for a one-year internship at a world-renowned stem cell research facility. What an incredible leap forward in your career, hands-on experience (essentially a first job, great “experience” for the resume) as well an expert education.
Where are the 14 California colleges participating in this program? Click below:
Let’s take a look at one of these college programs in action: find out what happened to a few of the students who received a Bridges award, crossing the gap between studying stem cell research and actually applying it.
HSU information is courtesy of Dr. Amy Sprowles, Associate Professor of Biological Sciences and Co-Director of the Bridges program at Humboldt State University (HSU), 279 miles north of San Francisco.
“The HSU Bridges program”, says Dr. Sprowles, “was largely developed by four people: Rollin Richmond, then HSU President, who worked closely with Susan Baxter, Executive Director of the CSU Program for Education and Research in Biotechnology, to secure the CIRM Bridges initiative; HSU Professor of Biological Sciences Jacob Varkey, who pioneered HSU’s undergraduate biomedical education program”, and Sprowles herself, at the time a lecturer with a PhD in Biochemistry.
The program has two parts: a beginning course in stem cell research, and a twelve-month internship in a premiere stem cell research laboratory. For HSU, these are at Stanford University, UC Davis, UCSF, or the Scripps Research Institute.
Like all CIRM Bridges programs, the HSU stem cell program is individually designed to suit the needs of its community.
Each of the 15 CIRM Bridges Programs fund up to ten paid internships, but the curriculum and specific activities of each are designed by their campus directors. The HSU program prepares Bridges candidates by requiring participation in a semester-long lecture and stem cell biology laboratory course before selection for the program: a course designed and taught by Sprowles since its inception.
She states, “The HSU pre-internship course ensures our students are trained in fundamental scientific concepts, laboratory skills and professional behaviors before entering their host laboratory. We find this necessary since, unlike the other Bridges campuses, we are 300+ miles away from the internship sites and are unable to fully support this kind of training during the experience. It also provides additional insights about the work ethic and mentoring needs of the individuals we select that are helpful in placing and supporting our program participants”.
How is it working?
Ten years after it began, 76 HSU students have completed the CIRM Bridges program at HSU. Of those, the overwhelming majority (over 85%) are committed to careers in regenerative medicine: either working in the field already, or continuing their education toward that goal.
But what happened to their lives? Take a brief look at the ongoing careers of a “Magnificent Seven” HSU Bridges scientists:
CARSTEN CHARLESWORTH: “Spurred by the opportunity to complete a paid internship at a world class research institution in Stem Cell Biology, I applied to the Humboldt CIRM Bridges program, and was lucky enough to be accepted. With a keen interest in the developing field of genome editing and the recent advent of the CRISPR-Cas9 system I chose to intern in the lab of a pioneer in the genome editing field, Dr. Matthew Porteus at Stanford, who focuses in genome editing hematopoietic stem cells to treat diseases such as sickle cell disease. In August of 2018 I began a PhD in Stanford’s Stem Cell and Regenerative Medicine program, where I am currently a second-year graduate student in the lab of Dr. Hiro Nakauchi, working on the development of human organs in interspecies human animal chimeras. The success that I’ve had and my acceptance into Stanford’s world class PhD program are a direct result of the opportunity that the CIRM Bridges internship provided me and the excellent training and instruction that I received from the Humboldt State Biology Program.”
ELISEBETH TORRETTI: “While looking for opportunities at HSU, I stumbled upon the CIRM Bridges program. It was perfect- a paid internship at high profile labs where I could expand my research skills for an entire year… the best fit (was) Jeanne Loring’s Lab at the Scripps Research Institute in La Jolla, CA. Dr. Loring is one of the premiere stem cell researchers in the world… (The lab’s) main focus is to develop a cure for Parkinson’s disease. (They) take skin cells known as fibroblasts and revert them into stem cells. These cells, called induced pluripotent stem cells (iPSCs) can then be differentiated into dopaminergic neurons and transplanted into the patient…. My project focused on a different disease: adenylate-cyclase 5 (ADCY5) — related dyskinesia. During my time at Dr. Loring’s lab I learned incredibly valuable research skills. I am now working in a mid-sized biotch company focusing on cancer research. I don’t think that would be possible in a competitive area like San Diego without my experience gained through the CIRM Bridges program.”
BRENDAN KELLY: “After completing my CIRM internship in Dr. Marius Wernig’s lab (in Stanford), I began working at a startup company called I Peace. I helped launch this company with Dr. Koji Tanabe, whom I met while working in my host lab. I am now at Cardiff University in Wales working on my PhD. My research involves using patient iPSC derived neurons to model Huntington’s disease. All this derived from my opportunity to partake in the CIRM-Bridges program, which opened doors for me.”
SAMANTHA SHELTON: “CIRM Bridges provided invaluable hands-on training in cell culture and stem cell techniques that have shaped my future in science. My CIRM internship in John Rubenstein’s Lab of Neural Development taught me amazing laboratory techniques such as stem cell transplantation as well as what goes into creating a harmonious and productive laboratory environment. My internship projects led to my first co-first author publication.
After my Bridges internship, I joined the Graduate Program for Neuroscience at Boston University. My PhD work aims to discover types of stem cells in the brain and how the structure of the brain develops early in life. During this time, I have focused on changes in brain development after Zika virus infection to better understand how microcephaly (small skulls and brains, often a symptom of Zika-DR) is caused. There is no doubt that CIRM not only made me a more competitive candidate for a doctoral degree but also provided me with tools to progress towards my ultimate goal of understanding and treating neurological diseases with stem cell technologies.”
DU CHENG: “Both my academic and business tracks started in the CIRM-funded…fellowship (at Stanford) where I invented the technology (the LabCam Microscope adapter) that I formed my company on (iDU Optics LLC). The instructor of the class, Dr. Amy Sprowles, encouraged me to carry on the idea. Later, I was able to get in the MD-PhD program at Weill Cornell Medical College because of the invaluable research experiences CIRM’s research program provided me. CIRM initiated the momentum to get me where I am today. Looking back, the CIRM Bridges Program is an instrumental jump-starter on my early career… I would not remotely be where I am without it.…”
CODY KIME: “Securing a CIRM grant helped me to take a position in the Nobel Prize winning Shinya Yamanaka Lab at the Gladstone Institutes, one of the most competitive labs in the new field of cell reprogramming. I then explored my own reprogramming interests, moving to the Kyoto University of Medicine, Doctor of Medical Sciences Program in Japan, and building a reprogramming team in the Masayo Takahashi Lab at RIKEN. My studies explore inducing cells to their highest total potential using less intrusive means and hacking the cell program. My systems are designed to inform my hypotheses toward a true お好みの細胞 (okonomi no cybo) technology, meaning ‘cells as you wish’ in Japanese, that could rapidly change any cell into another desired cell type or tissue.”
SARA MILLS: “The CIRM Bridges program was the key early influencer which aided in my hiring of my first industry position at ViaCyte, Inc. Also a strongly CIRM funded institution, I was ultimately responsible for the process development of the VC-01™ fill, finish processes and cGMP documentation development. Most recently, with over two years at the boutique consulting firm of Dark Horse Consulting, Inc., I have been focusing on aseptic and cGMP manufacturing process development, risk analysis, CMC and regulatory filings, facility design and project management to advise growing cell and gene therapy companies, worldwide.”
Like warriors fighting to save lives, these young scientists are engaged in an effort to study and defeat chronic disease. It is to be hoped the California stem cell program will have its funding renewed, so the “Bridges” program can continue.
For more information on the Bridges program, which might help a young scientist (perhaps yourself) cut and paste the following URL:
One closing paragraph perhaps best sums up the Bridges experience:
“During my CIRM Bridges training in Stanford University, I was fortunate to work with Dr. Jill Helms, who so patiently mentored me on research design and execution. I ended up publishing 7 papers with her during the two-year CIRM internship and helped making significant progress of turning a Stem Cell factor into applicable therapeutic form, that is currently in preparation for clinical trial by a biotech company in Silicon Valley. I also learned from her how to write grants and publications, but more importantly, (to) never limit your potential by what you already know.” — Du Cheng
There’s no denying the fact that many people believe we’re on the cusp of a radical shift in the world of medicine and biotechnology. Over the past few years alone there’s been growing awareness about stem cells and their potential to provide cures for rare diseases. The results of early-stage research and preliminary clinical studies suggest that treatments for health problems like ALS, Sickle Cell Anemia, or blindness are on the horizon and that the potential for stem cells and their application could be limitless. With such promise for stem cell research, it’s no surprise that scientists and students alike are eager to jump in and pioneer what could be the next frontier in medicine.
Enter 120 college students, a handful of advisors, clinical trial participants and some of the nations’ brightest and highly-regarded researchers. On July 11th, they descended upon the Newport Beach Marriott for the opportunity to learn the latest and greatest about stem cells and successful clinical trials at the Bridges to Stem Cell Research conference.
This annual conference, which is supported and funded by CIRM, is one of two of our educational programs (the other is SPARK, that’s coming up August 7th at UC Davis). Bridges offer students an internship and the opportunity to get hands-on training and education in stem cell research at California state schools and community colleges, to prepare them for a career in stem cell research. This year’s conference was hosted and organized by the California State University, San Marcos Bridges Program.
Our goal is to provide a platform for meaningful learning to the next generation of stem cell scientists by making training accessible and giving them the skills necessary to succeed in this industry.
The Bridges conference is an opportunity for the students to showcase their research projects, learn valuable pitching and speaking skills and network with CIRM-supported scientists and their patients. The conference, spread over three days, is the highlight of the program for many of the students, and a treat for CIRM staff who get to see the next generation of scientists in action.
CIRM kicked off the conference with a “Wow me” workshop in which students learned the basics of delivering an “elevator pitch” – a 30-second explanation, in plain English, of what they do, why they do it and why people should care. The evening concluded with a reception dinner on the back lawn of the hotel.
The second day focused on talks by leading industry scientists as well as clinical trial participants in CIRM-funded trials and patient advocates. Later in the day, students participated in a “Pitch-Off” in which they were asked to put their new skills to use by creating a short video showcasing their best “elevator pitch”. Americans for Cures hosted dinner for the evening and spoke about the importance of advocacy and education in stem cell research.
The last day the Bridges conference featured student poster presentations and concluded with career workshops.
The Bridges conference is a once in a lifetime opportunity for the students. Most of them leverage the opportunity to get first-hand feedback on their most pressing questions. For those interested in careers in science and regenerative medicine, it also presents a great opportunity to talk and network with the scientists who are the true innovators of stem cell research.
If you’re interested in learning more about the Bridges conference, follow us on twitter (@CIRMnews, #CIRMBridges2018) and on Instagram (@CIRM_Stemcells).
Luane Beck holds Jordan in the emergency room while he suffers a prolonged seizure. Jordan’s seizures sometimes occur one after another with no break, and they can be deadly without emergency care. Photo courtesy San Francisco Chronicle’s Kim Clark
One of the toughest parts of my job is getting daily calls and emails from people desperate for a stem cell treatment or cure for themselves or a loved one and having to tell them that I don’t know of any. You can hear in their voice, read it in their emails, how hard it is for them to see someone they love in pain or distress and not be able to help them.
I know that many of those people may think about turning to one of the many stem cell clinics, here in the US and in Mexico and other countries, that are offering unproven and unapproved therapies. These clinics are offering desperate people a sense of hope, even if there is no evidence that the therapies they provide are either safe or effective.
And these “therapies” come with a big cost, both emotional and financial.
The San Francisco Chronicle this week launched the first in a series of stories they are doing about stem cells and stem cell research, the progress being made and the problems the field still faces.
One of the biggest problems, are clinics that offer hope, at a steep price, but no evidence to show that hope is justified. The first piece in the Chronicle series is a powerful, heart breaking story of one mother’s love for her son and her determination to do all she can to help him, and the difficult, almost impossible choices she has to make along the way.
A little turbulence, and a French press-like device, can help boost blood platelet production
Every year more than 21 million units of blood are transfused into people in the US. It’s a simple, life-saving procedure. One of the most important elements in transfusions are platelets, the cells that stop bleeding and have other healing properties. Platelets, however, have a very short shelf life and so there is a constant need to get more from donors. Now a new study from Japan may help fix that problem.
Platelets are small cells that break off much larger cells called megakaryocytes. Scientists at the Center for iPS Cell Research and Application (CiRA) created billions of megakaryocytes using iPS technology (which turns ordinary cells into any other kind of cell in the body) and then placed them in a bioreactor. The bioreactor then pushed the cells up and down – much like you push down on a French press coffee maker – which helped promote the generation of platelets.
In their study, published in the journal Cell, they report they were able to generate 100 billion platelets, enough to be able to treat patients.
In a news release, CiRA Professor Koji Eto said they have shown this works in mice and now they want to see if it also works in people:
“Our goal is to produce platelets in the lab to replace human donors.”
Stem Cell Photo of the Week
Students at the CIRM Bridges program practice their “elevator pitch”. Photo Kyle Chesser
This week we held our annual CIRM Bridges to Stem Cell Research conference in Newport Beach. The Bridges program provides paid internships for undergraduate and masters-level students, a chance to work in a world-class stem cell research facility and get the experience needed to pursue a career in science. The program is training the next generation of stem cell scientists to fill jobs in California’s growing stem cell research sector.
This year we got the students to practice an “elevator Pitch”, a 30 second explanation, in plain English, of what they do, why they do it and why people should care. It’s a fun exercise but also an important one. We want scientists to be able to explain to the public what they are doing and why it’s important. After all, the people of California are supporting this work so they have a right to know, in language they can understand, how their money is changing the face of medicine.
In need of an extra dose of inspiration? You might read a great book or listen to that podcast your friend recommended. You might even take a stroll along the beach. But I can do you one better: go to a conference poster session where young stem cell scientists describe their research.
That’s what I did last week at the City College of San Francisco’s (CCSF) Bioscience Symposium held at UC San Francisco’s Genentech Hall. It’s a day-long conference that showcases the work of CCSF Bioscience interns and gives them a chance to present the results of their research projects, network with their peers and researchers, hear panelists talk about careers in biotechnology and participate in practice job interviews.
CCSF’s CIRM Bridges Scholars (clockwise from top left): Vanessa Lynn Herrara, Viktoriia Volobuieva, Christopher Nosworthy and Sofiana E. Hamama.
CCSF’s CIRM Bridges Scholars (clockwise from top left): Seema Niddapu, Mark Koontz, Karolina Kaminska and Iris Avellano
Eight of the dozens of students in attendance at the Symposium are part of the CIRM-funded Bridges Stem Cell Internship program at CCSF. It’s one of 14 CIRM Bridges programs throughout the state that provides paid stem cell research internships to students at universities and colleges that don’t have major stem cell research programs. Each Bridges internship includes thorough hands-on training and education in stem cell research, and direct patient engagement and outreach activities that engage California’s diverse communities.
In the CCSF Bridges Program, directed by Dr. Carin Zimmerman, the students do a 9-month paid internship in top notch labs at UCSF, the Gladstone Institutes and Blood System Research Institute. As I walked from poster to poster and chatted with each Bridges scholar, their excitement and enthusiasm for carrying out stem cell research was plain to see. It left me with the feeling that the future of stem cell research is in good hands and, as I walked into the CIRM office the next day, I felt re-energized to tackle the Agency’s mission to accelerate stem cell treatment for patients with unmet medical needs. But don’t take my word for it, listen to the enthusiastic perspectives of Bridges scholars Mark Koontz and Iris Avellano in this short video.
Jan Nolta is a scientific rockstar. She is a Professor at UC Davis and the Director of the Stem Cell Program at the UC Davis School of Medicine. Her lab’s research is dedicated to developing stem cell-based treatments for Huntington’s disease (HD). Jan is a tireless advocate for both stem cell and HD research and you’ll often see her tweeting away about the latest discoveries in the field to her followers.
What I admire most about Dr. Nolta is her dedication to educating and mentoring young students. Dr. Nolta helped write the grant that funded the CIRM Bridges master’s program at Sacramento State in 2009. Over the years, she has mentored many Bridges students (we blogged about one student earlier this year) and also high school students participating in CIRM’s SPARK high school internship program. Many of her young trainees have been accepted to prestigious colleges and universities and gone on to pursue exciting careers in STEM.
I reached out to Dr. Nolta and asked her to share her thoughts on the importance of mentoring young scientists and supporting their career ambitions. Below is a summary of our conversation. I hope her passion and devotion will inspire you to think about how you can get involved with student mentorship in your own career.
Describe your career path from student to professor.
I was an undergraduate student at Sacramento State University. I was a nerdy student and did research on sharks. I was planning to pursue a medical degree, but my mentor, Dr. Laurel Heffernan, encouraged me to consider science. I was flabbergasted at the suggestion and asked, “people pay you to do this stuff??” I didn’t know that you could be paid to do lab research. My life changed that day.
I got my PhD at the University of Southern California. I studied stem cell gene therapy under Don Kohn, who was a fabulous mentor. After that, I worked in LA for 15 years and then went back home to UC Davis in 2007 to direct their Stem Cell Program.
It was shortly after I got to Davis that I reconnected with my first mentor, Dr. Heffernan, and we wrote the CIRM Bridges grant. Davis has a large shared translational lab with seven principle investigators including myself and many of the Bridges students work there. Being a scientist can be stressful with grant deadlines and securing funding. Mentoring students is the best part of the job for me.
Why is it important to fund educational programs like Bridges and SPARK?
There is a serious shortage of well-trained specialists in regenerative medicine in all areas of the workforce. The field of regenerative medicine is still relatively new and there aren’t enough people with the required skills to develop and manufacture stem cell treatments. The CIRM Bridges program is critical because it trains students who will fill those key manufacturing and lab manager jobs. Our Bridges program at Sacramento State is a two-year master’s program in stem cell research and lab management. They are trained at the UC Davis Good Manufacturing Practice (GMP) training facility and learn how to make induced pluripotent stem cells (iPSCs) and other stem cell products. There aren’t that many programs like ours in the country and all of our students get competitive job offers after they complete our program.
We are equally passionate about our high school SPARK program. It’s important to capture students’ interests early whether they want to be a scientist or not. It’s important they get exposed to science as early as possible and even if they aren’t going to be a scientist or healthcare professional, it’s important that they know what it’s about. It’s inspiring how many of these students stay in STEM (Science, Technology, Engineering and Math) because of this unique SPARK experience.
Jan Nolta with the 2016 UC Davis SPARK students.
Can you share a student success story?
I’m so proud of Ranya Odeh. She was a student in our 2016 SPARK program who worked in my lab. Ranya received a prestigious scholarship to Stanford largely due to her participation in the CIRM SPARK program. I got to watch her open the letter on Instagram, and it was a really incredible experience to share that part of her life.
I’m also very proud of our former Bridges student Jasmine Carter. She was a mentor to one of our SPARK students Yasmine this past summer. She was an excellent role model and her passion for teaching and research was an inspiration to all of us. Jasmine was hoping to get into graduate school at UC Davis this fall. She not only was accepted into the Neuroscience Graduate Program, but she also received a prestigious first year program fellowship!
UC Davis Professors Jan Nolta and Kyle Fink with CIRM Bridges student Jasmine Carter
[Side note: We’ve featured Ranya and Jasmine previously on the Stem Cellar and you can read about their experiences here and here.]
Why is mentoring important for young students?
I can definitely relate to the importance of having a mentor. I was raised by a single mom, and without scholarships and great mentors, there’s no way I would be where I am today. I’m always happy to help other students who think maybe they can’t do science because of money, or because they think that other people know more than they do or are better trained. Everybody who wants to work hard and has a passion for science deserves a chance to shine. I think these CIRM educational programs really help the students see that they can be what they dream they can be.
What are your favorite things about being a mentor?
Everyday our lab is full of students, science, laughter and fun. I love coming in to the lab. Our young people bring new ideas, energy and great spirit to our team. I think every team should have young trainees and high school kids working with them because they see things in a different way.
Do you have advice for mentoring young scientists?
You can sum it up in one word: Listen. Ask them right away what their dreams are, where do they imagine themselves in the future, and how can you help them get there. Encourage them to always ask questions and let them know that they aren’t bothering you when they do. I also let my students know that I’m happy to be helping them and that the experience is rewarding for me as well.
So many students are shy when they first start in the lab and don’t get all that they can out of the experience. I always tell my students of any age: what you really want to do is try in life. Follow your tennis ball. Like when a golden retriever sees a tennis ball going by, everything else becomes secondary and they follow that ball. You need to find what that tennis ball is for you and then just try to follow it.
What advice can you give to students who want to be scientific professors or researchers?
Find somebody who is a good mentor and cares about you. Don’t go into a lab where the Principle Investigator (PI) is not there most of the time. You will get a lot more out of the experience if you can get input from the PI.
A good mentor is more present in the lab and will take you to meetings and introduce you to people. I find that often students read papers from well-established scientists, and they think that their positions are unattainable. But if they can meet them in person at a conference or a lecture, they will realize that all of the established scientists are people too. I want young students to know that they can do it too and these careers are attainable for anybody.
Nothing makes a professional sports team prouder than its homegrown talent. Training and mentoring a promising, hard-working athlete who eventually helps carry the team to a championship can lift the spirits of an entire city.
Here at CIRM, we hold a similar sense of pride in Brian Fury, one of our own homegrown all-stars. Nearly a decade ago, Brian was accepted into the inaugural class of CIRM’s Bridges program which provides paid stem cell research internships to students at California universities and colleges that don’t have major stem cell research programs. The aim of the program, which has trained over 1200 students to date, is to build the stem cell work force here in California to accelerate stem cell treatments to patients with unmet medical needs.
A CIRM full circle Today, Brian is doing just that as manager of manufacturing at the UC Davis Institute for Regenerative Cures (IRC) where he leads the preparation of stem cell therapy products for clinical trials in patients. It was at UC Davis that he did his CIRM Bridges internship as a Sacramento State masters student back in 2009. So, he’s really come full circle, especially considering he currently works in a CIRM-funded facility and manufactures stem cell therapy products for CIRM-funded clinical trials.
“Many of the technicians we have in the [cell manufacturing] facility are actually from the Bridges program CIRM has funded, and were educated by us,” Gerhard Bauer, Brian’s boss and director of the facility, explained to me. “Brian, in particular, has made me incredibly proud. To witness that the skills and knowledge I imparted onto my student would make him such an integral part of our program and would lead to so many novel products to be administered to people, helping with so many devastating diseases is a very special experience. I treasure it every day.”
“It sustains me” Brian’s career path wasn’t always headed toward stem cell science. In a previous life, he was an undergrad in computer management information systems. It was a required biology class at the time that first sparked his interest in the subject. He was fascinated by the course and was inspired by his professor, Cathy Bradshaw. He still recalls a conversation he had with her to better understand her enthusiasm for biology:
“I asked her, ‘what is it about biology that really made you decide this is what you wanted to do?’ And she just said, ‘It sustains me. It is air in my lungs.’ It was what she lived and breathed. That really stuck with me early on.“
Still, Brian went on to earn his computer degree and worked as a computer professional for several years after college. But when the dot com boom went bust in the early 2000’s, Brian saw it as a sign to re-invent himself. Remembering that course with Professor Bradshaw, he went back to school to pursue a biology degree at Sacramento State University.
On a path before there was a path Not content with just his textbooks and lectures at Sac State, Brian offered to volunteer in any lab he could find, looking for opportunities to get hands-on experience:
Brian at work during his Sacramento State days.
“I was really hungry to get involved and I really wanted to not just be in class and learning about all these amazing things in biology but I also wanted to start putting them to work. And so, I looked for any opportunity that I could to become actively involved in actually seeing how biology really works and not just the theory.”
This drive to learn led to several volunteer stints in labs on campus as well as a lab manager job. But it was an opportunity he pursued as he was finishing up his degree that really set in motion his current career path. Gerhard Bauer happened to be giving a guest lecture at Sac State about UC Davis’ efforts to develop a stem cell-based treatment for HIV. Hearing that talk was an epiphany for Brian. “That’s really what hooked me in and helped determine that this is definitely the field that I want to enter into. It was my stepping off point.”
Brian Fury (center) flanked by mentors Gerhard Bauer (left) and Jan Nolta (right)
Inspired, Brian secured a volunteering gig on that project at UC Davis – along with all his other commitments at Sac State – working under Bauer and Dr. Jan Nolta, the director of the UC Davis Stem Cell Program.
That was 2008 and this little path Brian was creating by himself was just about to get some serious pavement. The next year, Sacramento State was one of sixteen California schools that was awarded the CIRM Bridges to Stem Cell Research grant. Their five-year, $3 million award (the total CIRM investment for all the schools was over $55 million) helped support a full-blown, stem cell research-focused master’s program which included 12-month, CIRM-funded internships. One of the host researchers for the internships was, you guessed it, Jan Nolta at UC Davis.
Good Manufacturing Practice (GMP) was a good move Applying to this new program was a no brainer for Brian and, sure enough, he was one of ten students selected for the first-year class. His volunteer HIV project in the Nolta lab seamlessly dovetailed into his Bridges internship project. He was placed under the mentorship of Dr. Joseph Anderson, a researcher in the Nolta lab at the time, and gained many important skills in stem cell research. Brian’s project focused on a stem cell and gene therapy approach to making HIV-resistant immune cells with the long-term goal of eradicating the virus in patients. In fact, follow on studies by the Anderson lab have helped lead to a CIRM-funded clinical trial, now underway at UC Davis, that’s testing a stem cell-based treatment for HIV/AIDs patients.
After his Bridges internship came to a close, Brian worked on a few short-term research projects at UC Davis but then found himself in a similar spot: needing to strike out on a career path that wasn’t necessarily clearly paved. He reached out to Nolta and Bauer and basically cut to the chase in an email asking, “do you know anybody?”. Bauer reply immediately, “yeah, me!”. It was late 2011 and UC Davis had built a Good Manufacturing Practice (GMP) facility with the help of a CIRM Major Facility grant. Bauer only had one technician at the time and work was starting to pick up.
The Good Manufacturing Practice (GMP) facility in UC Davis’ Institute for Regenerative Cures.
A GMP facility is a specialized laboratory where clinical-grade cell products are prepared for use in people. To ensure the cells are not contaminated, the entire lab is sealed off from the outside environment and researchers must don full-body lab suits. We produced the video below about the GMP facility just before it opened.
Bauer knew Brian would be perfect at their GMP facility:
“Brian was a student in the first cohort of CIRM Bridges trainees and took my class Bio225 – stem cell biology and manufacturing practices. He excelled in this class, and I also could observe his lab skills in the GMP training part incorporated in this class. I was very lucky to be able to hire Brian then, since I knew what excellent abilities he had in GMP manufacturing.”
CIRM-supported student now supporting CIRM-funded clinical trials
Brian Fury suited up in GMP facility
Since then, Brian has worked his way up to managing the entire GMP facility and its production of cell therapy products. At last count, he and the five people he supervises are juggling sixteen cell manufacturing projects. One of his current clients is Angiocrine which has a CIRM-funded clinical trial testing a cell therapy aimed to improve the availability and engraftment of blood stem cell transplants. This treatment is geared for cancer patients who have had their cancerous bone marrow removed by chemotherapy.
When a company like Angiocrine approaches Brian at the GMP facility, they already have a well-defined method for generating their cell product. Brian’s challenge is figuring out how to scale up that process to make enough cells for all the patients participating in the clinical trial. And on top of that, he must design the procedures for the clean room environment of the GMP facility, where every element of making the cells must be written down and tracked to demonstrate safety to the Food and Drug Administration (FDA).
The right time, the right place…and a whole bunch of determination and passion It’s extremely precise and challenging work but that’s what makes it so exciting for Brian. He tells me he’s never bored and always wakes up looking forward to what each day’s challenges will bring and figuring out how he and his team are going get these products into the clinic. It’s a responsibility he takes very seriously because he realizes what it means for his clients:
“I invest as much energy and passion and commitment into these projects as I would my own family. This is extremely important to me and I feel so incredibly fortunate to have the opportunity to work on things like this. The reality is, in the GMP, people are bringing their life’s work to us in the hopes we can help people on the other end. They share all their years of development, knowledge and experience and put it in our hands and hope we can scale this up to make it meaningful for patients in need of these treatments.”
Despite all his impressive accomplishments, Brian is a very modest guy using phrases like “I was just in the right place at the right time,” during our conversation. But I was glad to hear him add “and I was the right candidate”. Because it’s clear to me that his determination and passion are the reasons for his success and is the epitome of the type of researcher CIRM had hoped its investment in the Bridges program and our SPARK high school internship program would produce for the stem cell research field.
That’s why we’ll be brimming over with an extra dose of pride on the day that one of Brian’s CIRM-funded stem cell therapy products reaches the goal line with an FDA approval.