THIS BLOG IS ALSO AVAILABLE AS AN AUDIOCAST ON SPOTIFY Credit : Allison Dougherty, Broad Communications For Sharif Tabebordbar, finding a gene therapy for genetic muscle wasting diseases was personal. When he was a teenager, his father was diagnosed with a rare genetic muscle disease that eventually left him unable to walk. In an interview … Continue reading A personal reason to develop a better gene therapy
Muscular Dystrophy
Repairing damaged muscles
Close-up of the arm of a 70-year-old male patient with a torn biceps muscle as a result of a bowling injury; Photo courtesy Science Photo Library In the time of coronavirus an awful lot of people are not just working from home they’re also working out at home. That’s a good thing; exercise is a … Continue reading Repairing damaged muscles
A scalable, clinic-friendly recipe for converting skin cells to muscle cells
Way back in 1987, about two decades before Shinya Yamanaka would go on to identify four proteins that can reprogram skin cells into induced pluripotent stem cells (iPSCs), Harold Weintraub’s lab identified the first “master control” protein, MyoD, which can directly convert a skin cell into a muscle cell. Though MyoD opened up new approaches … Continue reading A scalable, clinic-friendly recipe for converting skin cells to muscle cells
Stem Cell Roundup: Improving muscle function in muscular dystrophy; Building a better brain; Boosting efficiency in making iPSC’s
Here are the stem cell stories that caught our eye this week. Photos of the week TGIF! We’re so excited that the weekend is here that we are sharing not one but TWO amazing stem cell photos of the week. Photo #1 is borrowed from a blog we wrote earlier this week about a new … Continue reading Stem Cell Roundup: Improving muscle function in muscular dystrophy; Building a better brain; Boosting efficiency in making iPSC’s
Stem Cell Stories that Caught Our Eye: GPS for Skin & Different Therapies for Aging vs. Injured Muscles?
Skin stem cells specialize into new skin by sensing neighborhood crowding When embarking on a road trip, the GPS technology inside our smartphones helps us know where we are and how to get where we’re going. The stem cells buried in the deepest layers of our skin don’t have a GPS and yet, they do … Continue reading Stem Cell Stories that Caught Our Eye: GPS for Skin & Different Therapies for Aging vs. Injured Muscles?
Stem Cell Stories That Caught our Eye: Stem Cell Therapies for Stroke and Duchenne Muscular Dystrophy Patients
With the Thanksgiving holiday behind us, we’re back to the grind at CIRM. Here are two exciting CIRM-funded stem cell stories that happened while you were away. Stanford Scientists Are Treating Stroke Patients with Stem Cells Smithsonian Magazine featured the work of a CIRM-funded scientist in their December Magazine issue. The article, “A Neurosurgeon’s Remarkable … Continue reading Stem Cell Stories That Caught our Eye: Stem Cell Therapies for Stroke and Duchenne Muscular Dystrophy Patients
Cured by Stem Cells
To get anywhere you need a good map, and you need to check it constantly to make sure you are still on the right path and haven’t strayed off course. A year ago the CIRM Board gave us a map, a Strategic Plan, that laid out our course for the next five years. Our Annual … Continue reading Cured by Stem Cells
Stem cells have a neat trick to prevent tissue scarring
A CIRM-funded study from the Stanford University School of Medicine has discovered that stem cells in muscle tissue “police themselves” to reduce fibrosis or the buildup of scar tissue. The ability to prevent scarring could promote anti-aging properties by keeping muscles healthy and functional and could also benefit patients with muscle wasting diseases like muscular … Continue reading Stem cells have a neat trick to prevent tissue scarring
Using skin cells to repair damaged hearts
When someone has a heart attack, getting treatment quickly can mean the difference between life and death. Every minute delay in getting help means more heart cells die, and that can have profound consequences. One study found that heart attack patients who underwent surgery to re-open blocked arteries within 60 minutes of arriving in the … Continue reading Using skin cells to repair damaged hearts
Scientists find new stem cell target for regenerating aging muscles
Today I’m going to use our former governor Arnold Schwarzenegger as an example of what happens to our muscles when we age. One of Arnold’s many talents when he was younger was being a professional bodybuilder. As you can see in this photo, Arnold worked hard to generate an impressive amount of muscle that landed … Continue reading Scientists find new stem cell target for regenerating aging muscles