Before joining CIRM I thought OCT4 was a date on the calendar. But a new study says it may be a lot closer to a date with destiny, because this study says OCT4 helps determine what kinds of cell a stem cell will become. Now, before we go any further I should explain for people … Continue reading Unlocking the secrets of how stem cells decide what kind of cell they’re going to be
transcription factor
Filling the Holes in our Understanding of Stem Cell Fate
How does a single-celled human embryo transform into a human body with intricate organ systems containing trillions of specialized cells? Step into any college lecture discussing this question and I bet “transcription factors” is a phrase you’ll often hear. Transcription factors are DNA-binding proteins that act as cell fate control switches during development. For cells … Continue reading Filling the Holes in our Understanding of Stem Cell Fate
A cardiac love triangle: how transcription factors interact to make a heart
Here’s a heartfelt science story for all those Valentine’s day fans out there. Scientists from the Gladstone Institutes have identified how a group of transcription factors interact during embryonic development to make a healthy heart. Their work will increase our biological understanding of how the heart is formed and could produce new methods for treating … Continue reading A cardiac love triangle: how transcription factors interact to make a heart
CIRM-Funded Scientists Build a Better Neuron; Gain New Insight into Motor Neuron Disease
Each individual muscle in our body—no matter how large or how small—is controlled by several types of motor neurons. Damage to one or more types of these neurons can give rise to some of the most devastating motor neuron diseases, many of which have no cure. But now, stem cell scientists at UCLA have manufactured … Continue reading CIRM-Funded Scientists Build a Better Neuron; Gain New Insight into Motor Neuron Disease
The Stem Cellar 