When Frank Gonzales was diagnosed with colorectal cancer in November 2010 it was the start of a long fight against the disease. Chemotherapy helped keep the cancer in check, but it wasn’t a cure. So when Frank heard about a new experimental treatment, that seeks out and destroys cancer stem cells, he was intrigued. Frank … Continue reading Pioneering patients heroes of early clinical trials
Cancer
CIRM fights cancer: $56 million for 5 clinical trials to vanquish tumors for good
[This is the first of three stories on CIRM’s Cancer Fight that we will post this week. Tomorrow’s will discuss two projects that attack cancer stem cells directly and Thursday's will describe three projects that help our immune system wipe out the traitorous cells.] It’s back—two words we would like to remove from the cancer … Continue reading CIRM fights cancer: $56 million for 5 clinical trials to vanquish tumors for good
Funding a clinical trial for deadly cancer is a no brainer
The beast of cancers For a disease that is supposedly quite rare, glioblastoma seems to be awfully common. I have lost two friends to the deadly brain cancer in the last few years. Talking to colleagues and friends here at CIRM, it’s hard to find anyone who doesn’t know someone who has died of it. … Continue reading Funding a clinical trial for deadly cancer is a no brainer
Helping patient’s fight back against deadliest form of skin cancer
Caladrius Biosciences has been funded by CIRM to conduct a Phase 3 clinical trial to treat the most severe form of skin cancer: metastatic melanoma. Metastatic melanoma is a disease with no effective treatment, only around 15 percent of people with it survive five years, and every year it claims an estimated 10,000 lives in … Continue reading Helping patient’s fight back against deadliest form of skin cancer
Stem cell stories that caught our eye: diabetes drug hits cancer, video stem cell tracker and quick n’ easy stem cells for fatal lung disease
Teaching an old drug new tricks. One the quickest way to get a drug to market is to find one that’s already been FDA approved for other diseases. Reporting this week in Cell Metabolism, researchers from London and Madrid identified the mechanisms that enable the anti-diabetic drug, metformin, to kill pancreatic cancer stem cells (PanCSCs). … Continue reading Stem cell stories that caught our eye: diabetes drug hits cancer, video stem cell tracker and quick n’ easy stem cells for fatal lung disease
Bye Bye BORIS: Gene Silencing Gives Cancer Stem Cells the Boot
A popular theory behind why cancer tumors recur post treatment is the existence of cancer stem cells (CSCs). These cells have stem cell-like qualities and are stubbornly resistant to common cancer cell killing techniques such as radiation and chemotherapy. CSCs are resilient and can reproduce themselves after all other cancer cells die off, creating new … Continue reading Bye Bye BORIS: Gene Silencing Gives Cancer Stem Cells the Boot
New Regenerative Liver Cells Identified
It’s common knowledge that your liver is a champion when it comes to regeneration. It’s actually one of the few internal organs in the human body that can robustly regenerate itself after injury. Other organs such as the heart and lungs do not have the same regenerative response and instead generate scar tissue to protect … Continue reading New Regenerative Liver Cells Identified
Stem cell stories that caught our eye: shutting down cancer stem cells, safer BMT, better gene therapy and a 3rd ear
Here are some stem cell stories that caught our eye this past week. Some are groundbreaking science, others are of personal interest to us, and still others are just fun. A new route to shut down cancer stem cells. A team at Texas A&M University has discovered a specific protein’s role in keeping cancer stem … Continue reading Stem cell stories that caught our eye: shutting down cancer stem cells, safer BMT, better gene therapy and a 3rd ear
Sonic Hedgehog provides pathway to fight blood cancers
For a lot of people Sonic Hedgehog is a video game. But for stem cell researcher Dr. Catriona Jamieson it is a signaling pathway in the body that offers a way to tackle and defeat some deadly blood cancers. Dr. Jamieson - a researcher at the University of California, San Diego (UCSD) - has a … Continue reading Sonic Hedgehog provides pathway to fight blood cancers
Two studies show genes and their switches critical to brain cancer’s resistance to therapy
Two California teams discovered genetic machinery that cancer stem cells in high-grade brain cancers use to evade therapy. One CIRM-funded team at Cedars-Sinai in Los Angeles pinpointed a family of genes that turn off other genes that chemotherapy targets —effectively hiding them from the chemo. The other team at the University of California, San Diego … Continue reading Two studies show genes and their switches critical to brain cancer’s resistance to therapy
The Stem Cellar 