Here’s a heartfelt science story for all those Valentine’s day fans out there. Scientists from the Gladstone Institutes have identified how a group of transcription factors interact during embryonic development to make a healthy heart. Their work will increase our biological understanding of how the heart is formed and could produce new methods for treating … Continue reading A cardiac love triangle: how transcription factors interact to make a heart
Basic Research
Timing is everything: could CRISPR gene editing push CIRM to change its rules on funding stem cell research?
Talk about timely. When we decided, several months ago, to hold a Standards Working Group (SWG) meeting to talk about the impact of CRISPR, a tool that is transforming the field of human gene editing, we had no idea that our meeting would fall smack in the midst of a flurry of news stories about … Continue reading Timing is everything: could CRISPR gene editing push CIRM to change its rules on funding stem cell research?
New drug kicks the cancer stem cell addiction
Did you know that cancer stem cells have an addiction problem? This might sound bizarre, but the science checks out. Cancer stem cells are found in many different types of cancer tumors. They have the uncanny ability to survive even the most aggressive forms of treatment. After weathering the storm, cancer stem cells are able … Continue reading New drug kicks the cancer stem cell addiction
Timing Matters: Slowly Dividing Stem Cells Lead to Small Brains
One hundred billion nerve cells working together empowering us to see, walk, think, speak, remember: the human brain is a stunning machine. Even more stunning is its formation in the growing fetus. It starts with a set of neural, or brain, stem cells in the early embryo. Then with each cell division, more and more cells … Continue reading Timing Matters: Slowly Dividing Stem Cells Lead to Small Brains
Wiping out a cell’s identity shifts cellular reprogramming into high gear
If stretched out end to end, the DNA in just one cell of your body would reach a whopping six feet in length. A complex cellular structure called chromatin – made up of coils upon coils of DNA and protein – makes it possible to fit all that DNA into a single cell nucleus that’s … Continue reading Wiping out a cell’s identity shifts cellular reprogramming into high gear
Using baking ingredient to create “nano” bombs and destroy cancer stem cells
"I am not a cook". Richard Nixon and the baking ingredient that could help win the "war on cancer" In 1971 President Richard Nixon declared a “war on cancer” and signed the National Cancer Act into law. Forty years later we’re still waging that war, and cancer is still one of the leading causes of … Continue reading Using baking ingredient to create “nano” bombs and destroy cancer stem cells
Meet the proteins that tell stem cells where to move and how
Word cloud art work which shows all the proteins identified by the researchers The environment you grow up in can have a huge influence on how you turn out. That applies to people, and to stem cells too. Now a new study has identified 60 proteins that can have a big impact on how … Continue reading Meet the proteins that tell stem cells where to move and how
Stem cells could offer hope for deadly childhood muscle wasting disease
Duchenne muscular dystrophy (DMD) is a particularly nasty rare and fatal disease. It predominantly affects boys, slowly robbing them of their ability to control their muscles. By 10 years of age, boys with DMD start to lose the ability to walk; by 12, most need a wheelchair to get around. Eventually they become paralyzed, and … Continue reading Stem cells could offer hope for deadly childhood muscle wasting disease
New type of diabetes caused by old age may be treatable
I’m going to tell you a secret: I love sugar. I love it so much that as a little kid my mom used to tell me scary stories about how my teeth would fall out and that I might get diabetes one day if I ate too many sweets. Thankfully, none of these things happened. … Continue reading New type of diabetes caused by old age may be treatable
A Fishy Tale: A gene that blocks regeneration in fish blocks cancer in humans
Evolution is a fascinating thing. Over time, the human race has evolved from cavemen to a bustling civilization fueled by technology, science, and economics. While we’ve gained many abilities that separate us from other mammals and our closest ancestors, the apes, we’ve also lost a number of skills along the way. One of them is … Continue reading A Fishy Tale: A gene that blocks regeneration in fish blocks cancer in humans
The Stem Cellar 