If you are born with Severe Combined Immunodeficiency (SCID), your childhood is anything but normal. You don’t get to play with other kids, or be held by your parents. You can’t even breathe the same air. And, without treatment, you probably won’t live past your first year. This is the reality of SCID, also called … Continue reading Gene Therapy Beats Half-Matched Stem Cell Transplant in Side-by-Side Comparison to Treat ‘Bubble Baby’ Disease
Research News
Stem Cell Scientists Reconstruct Disease in a Dish; Gain Insight into Deadly Form of Bone Cancer
The life of someone with Li-Fraumeni Syndrome (LFS) is not a pleasant one. A rare genetic disorder that usually runs in families, this syndrome is characterized by heightened risk of developing cancer—multiple types of cancer—at a very young age. People with LFS, as the syndrome is often called, are especially susceptible to osteosarcoma, a form … Continue reading Stem Cell Scientists Reconstruct Disease in a Dish; Gain Insight into Deadly Form of Bone Cancer
Cancer Cells Mimic Blood Vessels to Colonize the Body’s Farthest Reaches
Scientists at Cold Spring Harbor Laboratory have just uncovered the latest dirty trick in the cancer playbook—one that spurs the cancer cells to spread throughout the body and evade treatment. But importantly, they believe they may have found a way to counter it. Reporting today in the journal Nature, Cold Spring Harbor researchers describe how … Continue reading Cancer Cells Mimic Blood Vessels to Colonize the Body’s Farthest Reaches
Breast Cancer Tumors Recruit Immune Cells to the Dark Side
We rely on our immune system to stave off all classes of disease—but what happens when the very system responsible for keeping us healthy turns to the dark side? In new research published today, scientists uncover new evidence that reveals how breast cancer tumors can actually recruit immune cells to spur the spread of disease. … Continue reading Breast Cancer Tumors Recruit Immune Cells to the Dark Side
New understanding of the inner workings of our genetic tool kit should help us make smarter repairs
For young biology students the steps from genes to their function becomes a mantra: DNA makes RNA and RNA makes protein. But it is really not quite that simple. A few different types of RNA act along the path and we are now learning that the structure, or shape, of the individual RNA molecules affects … Continue reading New understanding of the inner workings of our genetic tool kit should help us make smarter repairs
Pathway discovered that could yield therapies to prevent hearts turning to “bone”
In the Rolling Stones’ lyrics having a “Heart of Stone” protected you from heartbreak. But over a million Americans are developing hearts of bone and it could kill them. CIRM-funded researchers at the Gladstone Institutes think they have uncovered the path to this destructive hardening of the heart and that could lead to therapies to … Continue reading Pathway discovered that could yield therapies to prevent hearts turning to “bone”
Pioneer’s 25-year struggle to treat blindness
Being a pioneer is never easy. You are charting unknown territory, tackling problems that have defeated others before you. You have to overcome so many obstacles that at times the challenge can seem insurmountable. But for those who succeed in reaching their goal, the rewards can be extraordinary. Last month Italian researcher Graziella Pellegrini saw … Continue reading Pioneer’s 25-year struggle to treat blindness
One-Time, Lasting Treatment for Sickle Cell Disease May be on Horizon, According to New CIRM-Funded Study
For the nearly 1,000 babies born each year in the United States with sickle cell disease, a painful and arduous road awaits them. The only cure is to find a bone marrow donor—an exceedingly rare proposition. Instead, the standard treatment for this inherited blood disorder is regular blood transfusions, with repeated hospitalizations to deal with … Continue reading One-Time, Lasting Treatment for Sickle Cell Disease May be on Horizon, According to New CIRM-Funded Study
Stay on Target: Scientists Create Chemical ‘Homing Devices’ that Guide Stem Cells to Final Destination
When injecting stem cells into a patient, how do the cells know where to go? How do they know to travel to a specific damage site, without getting distracted along the way? Scientists are now discovering that, in some cases they do but in many cases, they don’t. So engineers have found a way to … Continue reading Stay on Target: Scientists Create Chemical ‘Homing Devices’ that Guide Stem Cells to Final Destination
Stem cell stories that caught our eye; progress toward artificial brain, teeth may help the blind and obesity
Here are some stem cell stories that caught our eye this past week. Some are groundbreaking science, others are of personal interest to us, and still others are just fun. More progress toward artificial brain. A team at the RIKEN Institute in Japan has used stem cells in a 3-D culture to create brain tissue … Continue reading Stem cell stories that caught our eye; progress toward artificial brain, teeth may help the blind and obesity
The Stem Cellar 