From left to right: Heather Dahlenburg, staff research associate; Jan Nolta, director of the Stem Cell Program; Jeannine Logan White, advanced cell therapy project manager; Sheng Yang, graduate student, Bridges Program, Humboldt State University, October 18, 2019. (AJ Cheline/UC Davis) At CIRM we are modest enough to know that we can't do everything by ourselves. … Continue reading Partners in health
muscle stem cells
Battling COVID and turning back the clock on stem cell funding
Coronavirus Battling the virus that causes COVID-19 is something that is top of everyone’s mind right now. That’s why CIRM is funding 17 different projects targeting the virus. But one of the most valuable tools in helping develop vaccines against a wide variety of diseases in the past is now coming under threat. We’ll talk … Continue reading Battling COVID and turning back the clock on stem cell funding
Perseverance: from theory to therapy. Our story over the last year – and a half
Some of the stars of our Annual Report It’s been a long time coming. Eighteen months to be precise. Which is a peculiarly long time for an Annual Report. The world is certainly a very different place today than when we started, and yet our core mission hasn’t changed at all, except to spring into … Continue reading Perseverance: from theory to therapy. Our story over the last year – and a half
Promising results from CIRM-funded projects
Severe Leukocyte Adhesion Deficiency-1 (LAD-1) is a rare condition that causes the immune system to malfunction and reduces its ability to fight off viruses and bacteria. Over time the repeated infections can take a heavy toll on the body and dramatically shorten a person’s life. But now a therapy, developed by Rocket Pharmaceuticals, is showing … Continue reading Promising results from CIRM-funded projects
Study shows that exercise rejuvenates muscle stem cells of old mice
Dr. Thomas Rando, Stanford University While we're all at home and practicing social distancing during this global pandemic, it has become a challenge to get in daily exercise. Aside from outward physical appearance, what other benefits does exercise hold? Dr. Thomas Rando and his team at Stanford University explored this question in more detail in … Continue reading Study shows that exercise rejuvenates muscle stem cells of old mice
Deep dive into muscle repair yields new strategies to combat Duchenne muscular dystrophy
Researchers at the Sanford Burnham Prebys Medical Discovery Institute (SBP) reported new findings this week that may lead to novel therapeutic strategies for people suffering from Duchenne muscular dystrophy (DMD). DMD, a muscle-wasting disease that affects 1 in 7250 males aged 5 to 24 years in the United States, is caused by a genetic mutation leading … Continue reading Deep dive into muscle repair yields new strategies to combat Duchenne muscular dystrophy
The Five Types of Stem Cells
When I give an “Intro to Stem Cells” presentation to, say, high school students or to a local Rotary Club, I begin by explaining that there are three main types of stem cells: (1) embryonic stem cells (ESCs) (2) adult stem cells and (3) induced pluripotent stem cells (iPSCs). Well, like most things in science, … Continue reading The Five Types of Stem Cells
Stem Cell Roundup: Artificial Embryos to Study Miscarriage and ALS Insight – Muscle Repair Cells Go Rogue
Stem Cell Image of the Week: Artificial embryos for studying miscarriage (Adonica Shaw) This week's stem cell image of the week comes from a team of researchers from The University of Cambridge who published research in Nature Cell Biology earlier this week indicating they’d achieved a breakthrough in stem cell research that resulted in the generation … Continue reading Stem Cell Roundup: Artificial Embryos to Study Miscarriage and ALS Insight – Muscle Repair Cells Go Rogue
A scalable, clinic-friendly recipe for converting skin cells to muscle cells
Way back in 1987, about two decades before Shinya Yamanaka would go on to identify four proteins that can reprogram skin cells into induced pluripotent stem cells (iPSCs), Harold Weintraub’s lab identified the first “master control” protein, MyoD, which can directly convert a skin cell into a muscle cell. Though MyoD opened up new approaches … Continue reading A scalable, clinic-friendly recipe for converting skin cells to muscle cells
Researchers find connection between aging muscles and mutations in stem cells
It’s a humbling fact of life that our muscles decline as we age which is why you didn’t see any 50-year-olds competing for Olympic Gold in figure skating at the 2018 Winter Games. You can blame your muscle stem cells for this. Also called satellite cells, these adult stem cells lie mostly dormant in muscle … Continue reading Researchers find connection between aging muscles and mutations in stem cells
The Stem Cellar 