It’s pretty easy to connect the dots between a lack of sleep and an increased risk of a deadly car crash. But what about an increased risk of cancer? A 2012 study of 101 women newly diagnosed with breast cancer found that those with inadequate sleep were more likely to have more aggressive tumors. Though … Continue reading Sleep inducing hormone puts breast cancer cells to rest
Basic Research
New approach could help turn back the clock and reverse damage for stroke patients
Stroke is the leading cause of serious, long-term disability in the US. Every year almost 800,000 people suffer from a stroke. The impact on their lives, and the lives of those around them can be devastating. Right now the only treatment approved by the US Food and Drug Administration (FDA) is tissue plasminogen activator or … Continue reading New approach could help turn back the clock and reverse damage for stroke patients
A look back at the last year – but with our eyes firmly on the future
Better. With that single word Randy Mills, our President and CEO, starts and ends his letter in our 2015 Annual Report and lays out the simple principle that guides the way we work at CIRM. Better. But better what? “Better infrastructure to translate early stage ideas into groundbreaking clinical trials. Better regulatory practices to advance … Continue reading A look back at the last year – but with our eyes firmly on the future
Unlocking the secrets of how stem cells decide what kind of cell they’re going to be
Before joining CIRM I thought OCT4 was a date on the calendar. But a new study says it may be a lot closer to a date with destiny, because this study says OCT4 helps determine what kinds of cell a stem cell will become. Now, before we go any further I should explain for people … Continue reading Unlocking the secrets of how stem cells decide what kind of cell they’re going to be
Tunable hydrogels guide stem cell differentiation
Differentiating stem cells into mature cells of adult tissue involves many intricate steps to get them to develop into the right cell types. You could compare the process to the careful adjustments you make when tuning a guitar. In the body, stem cells receive cues from their surrounding environment to mature into specific types of … Continue reading Tunable hydrogels guide stem cell differentiation
Stem cell stories that caught our eye: turning on T cells; fixing our brains; progress and trends in stem cells; and one young man’s journey to recover from a devastating injury
A healthy T cell Here are some stem cell stories that caught our eye this past week. Some are groundbreaking science, others are of personal interest to us, and still others are just fun. Directing the creation of T cells. To paraphrase the GOP Presidential nominee, any sane person LOVES, LOVES LOVES their T cells, … Continue reading Stem cell stories that caught our eye: turning on T cells; fixing our brains; progress and trends in stem cells; and one young man’s journey to recover from a devastating injury
From flies to mice: Improving stem cell therapy for degenerative eye diseases
Stem cell therapies for degenerative eye diseases sound promising – inject retinal progenitor cells derived from human pluripotent stem cells into the eye where they will integrate and replace damaged retinal tissue to hopefully restore sight. However, a significant road block is preventing these stem cell transplants from doing their job: the transplanted cells are … Continue reading From flies to mice: Improving stem cell therapy for degenerative eye diseases
Presentations at ISSCR that caught our eye: Stem cell clinical trials expand as work to improve our understanding of just how they work goes on in parallel
In a special edition of our weekly roundup, here are some highlights from just the first two days of the four-day annual meeting of the International Society for Stem Cell Research Seeing stem cells from both sides now. As the biggest gathering of stem cell researchers each year, the annual meeting of the International Society … Continue reading Presentations at ISSCR that caught our eye: Stem cell clinical trials expand as work to improve our understanding of just how they work goes on in parallel
Need a new ear, why not grow it from an apple?
That may be one of the strangest headlines you have read in a while, but believe me, the rest of this post is not going to be any less strange. And yet, the work behind that headline could open up the possibility of using everyday produce, such as apples and asparagus, as tools to help … Continue reading Need a new ear, why not grow it from an apple?
Filling the Holes in our Understanding of Stem Cell Fate
How does a single-celled human embryo transform into a human body with intricate organ systems containing trillions of specialized cells? Step into any college lecture discussing this question and I bet “transcription factors” is a phrase you’ll often hear. Transcription factors are DNA-binding proteins that act as cell fate control switches during development. For cells … Continue reading Filling the Holes in our Understanding of Stem Cell Fate
The Stem Cellar 