Devising a drug safety measuring stick in stem cell-derived heart muscle cells One of the mantras in the drug development business is “fail early”. That’s because most of the costs of getting a therapy to market occur at the later stages when an experimental treatment is tested in clinical trials in people. So, it’s best … Continue reading Stem cell stories that caught our eye: drug safety for heart cells, worms hijack plant stem cells & battling esophageal cancer
Author: Todd Dubnicoff
Rhythmic brain circuits built from stem cells
The TV commercial is nearly 20 years old but I remember it vividly: a couple is driving down a street when they suddenly realize the music on their tape deck is in sync with the repetitive activity on the street. From the guy casually dribbling a basketball to people walking along the sidewalk to the … Continue reading Rhythmic brain circuits built from stem cells
“Apples to Apples” analysis: induced pluripotent stem cell (iPSC) method doesn’t increase mutations
It’s full steam ahead for the development of induced pluripotent stem cell (iPSC)-derived clinical trials. That’s according to a group at the National Human Genome Research Institute in Bethesda, Maryland who report this week in PNAS that the process of reprogramming a skin cell into the embryonic stem cell-like state of an iPSC does not … Continue reading “Apples to Apples” analysis: induced pluripotent stem cell (iPSC) method doesn’t increase mutations
Mini-guts made from stem cells uncover mechanisms of viral infection in infants
Besides their chubby cheeks and cute little toes, I think what makes newborns so precious is how vulnerable they are in those first few days and months of life. For instance, infants are particularly easy targets for infections of the gut caused by enteroviruses. While healthy adults infected with these viruses may exhibit mild cold … Continue reading Mini-guts made from stem cells uncover mechanisms of viral infection in infants
Stories that caught our eye: new target for killing leukemia cancer stem cells and stem cell vesicles halt glaucoma
New stem cell target for acute myeloid leukemia (Karen Ring). A new treatment for acute myeloid leukemia, a type of blood cancer that turns bone marrow stem cells cancerous, could be in the works in the form of a cancer stem cell destroying antibody. Scientists from the NYU Langone Medical Center and the Memorial Sloan … Continue reading Stories that caught our eye: new target for killing leukemia cancer stem cells and stem cell vesicles halt glaucoma
Growing a rat pancreas in a mouse with stem cells & CRISPR: a solution for the organ shortage crisis?
Right now, about 120,000 Americans are on a waiting list for an organ transplant and 22 will die today before any organs become available. The plain truth is there aren’t enough organ donors to meet the demand. And according to the U.S. Department of Health and Human Services, the number of available organ donors has … Continue reading Growing a rat pancreas in a mouse with stem cells & CRISPR: a solution for the organ shortage crisis?
Stories that caught our eye: $20.5 million in new CIRM discovery awards, sickle cell disease cell bank, iPSC insights
CIRM Board launches a new voyage of Discovery (Kevin McCormack). Basic or early stage research is the Rodney Dangerfield of science; it rarely gets the respect it deserves. Yesterday, the CIRM governing Board showed that it not only respects this research, but also values its role in laying the foundation for everything that follows. The … Continue reading Stories that caught our eye: $20.5 million in new CIRM discovery awards, sickle cell disease cell bank, iPSC insights
Stories that caught our eye: frail bones in diabetics, ethics of future IVF, Alzheimer’s
The connection between diabetes and frail bones uncovered Fundamentally, diabetes is defined by abnormally high blood sugar levels. But that one defect over time carries an increased risk for a wide range of severe health problems. For instance, compared to healthy individuals, type 2 diabetics are more prone to poorly healing bone fractures – a … Continue reading Stories that caught our eye: frail bones in diabetics, ethics of future IVF, Alzheimer’s
Stem cell stories that caught our eye: designer socks for cancer patients, stem-cell derived stomachs and fighting off bone infections
Inspiring cancer patients with designer socks. (Karen Ring) Here’s a motivating story we found in the news this week about a cancer survivor who’s bringing inspiration to other cancer patients with designer socks. Yes, you read that correctly, socks. Jake Teitelbaum is a student at Wake Forest University and suffers from a rare form of blood … Continue reading Stem cell stories that caught our eye: designer socks for cancer patients, stem-cell derived stomachs and fighting off bone infections
Stem cell-derived pacemaker cells could help weak hearts keep the beat
In an average lifetime, the human heart dutifully beats more than 2.5 billion times. You can thank an area of the heart called the sinoatrial node, or SAN, which acts as the heart’s natural pacemaker. The SAN is made up of specialized heart muscle cells that, like a conductor leading an orchestra, dictates the rate … Continue reading Stem cell-derived pacemaker cells could help weak hearts keep the beat
The Stem Cellar 