If stretched out end to end, the DNA in just one cell of your body would reach a whopping six feet in length. A complex cellular structure called chromatin – made up of coils upon coils of DNA and protein – makes it possible to fit all that DNA into a single cell nucleus that’s … Continue reading Wiping out a cell’s identity shifts cellular reprogramming into high gear
Author: Todd Dubnicoff
Bringing down the gatekeeper for a stem cell-based Parkinson’s cure
On the surface, a stem cell-based cure for Parkinson’s disease seems pretty straight-forward. This age-related neurodegenerative disorder, which leads to progressively worsening tremors, slowness of movement and muscle rigidity, is caused by the death of a specific type of nerve cell, or neuron, that produces the chemical dopamine in a specific region of the brain. … Continue reading Bringing down the gatekeeper for a stem cell-based Parkinson’s cure
Smoking out Leukemia Cells to Prevent Cancer Relapse
Ninety-five percent of all patients with chronic myeloid leukemia (CML), carry a Frankenstein-like gene, called BCR-ABL, created from an abnormal fusion of two genes normally found on two separate chromosomes. Like a water faucet without a shutoff valve, the resulting mutant protein is stuck in an “on” position and leads to uncontrolled cell division and … Continue reading Smoking out Leukemia Cells to Prevent Cancer Relapse
Eyeing Stem Cell Therapies for Vision Loss
Back by popular demand (well, at least a handful of you demanded it!) we’re pleased to present the third installment of our Stem Cells in Your Face video series. Episodes one and two set out to explain – in a light-hearted, engaging and clear way – the latest progress in CIRM-funded stem cell research related … Continue reading Eyeing Stem Cell Therapies for Vision Loss
Have your cake and eat it too: Stem cells without the risk of tumors
A real stem cell tourism story Back in 2001, an Israeli boy suffering from Ataxia Telangiectasia, a genetic brain disease that affects movement, traveled to Russia for an unregulated stem cell treatment. His brain and spinal cord were injected with fetal stem cells though the exact composition of those cells was not known. Four years … Continue reading Have your cake and eat it too: Stem cells without the risk of tumors
Cell survival strategy gives mesenchymal stem cells their “paramedic” properties
A cell for all therapies Type “mesenchymal stem cells” into the federal online database of registered clinical trials, and you’ll get a sprawling list of 527 trials testing treatments for diabetes, multiple sclerosis as well as diseases of the kidney, lung, and heart, to name just a few. Mesenchymal stem cells (MSCs) have the capacity … Continue reading Cell survival strategy gives mesenchymal stem cells their “paramedic” properties
Bipolar Disorder-in-a-Dish: Game On for Finding New Drugs
The tragic path of biopolar disorder Ernest Hemingway, Kurt Cobain, Amy Winehouse and Virginia Woolf – the world lost their creativity too soon. Each took their own life or succumbed to substance abuse, most likely due to their struggles with bipolar disorder. Also called manic depression, bipolar disorder is one of the most severe types of … Continue reading Bipolar Disorder-in-a-Dish: Game On for Finding New Drugs
New Video: Spinal Cord Injury and a CIRM-Funded Stem Cell-Based Trial
Just 31 years old, Richard Lajara thought he was going to die. On September 9, 2011 he slipped on some rocks at a popular swimming hole and was swept down a waterfall headfirst into a shallow, rocky pool of water. Though he survived, the fall left him paralyzed from the waist down due to a … Continue reading New Video: Spinal Cord Injury and a CIRM-Funded Stem Cell-Based Trial
Keeping elderly cells old to understand the aging process
Aging is a key risk factor for many diseases, particularly disorders of the brain like Alzheimer’s or Parkinson’s, which primarily occur in the elderly. So a better understanding of the aging process should provide a better understanding of these neurodegenerative diseases. The induced pluripotent stem cell (iPSC) technique makes it possible to grow human brain … Continue reading Keeping elderly cells old to understand the aging process
Stem cell stories that caught our eye: new CRISPR fix for sickle cell disease, saving saliva stem cells, jumping genes in iPSCs and lung stem cells.
An end run around sickle cell disease with CRISPR The CRISPR-based gene editing technique has got to be the hottest topic in biomedical research right now. And I sense we’re only at the tip of the iceberg with more applications of the technology popping up almost every week. Just two days ago, researchers at the Dana … Continue reading Stem cell stories that caught our eye: new CRISPR fix for sickle cell disease, saving saliva stem cells, jumping genes in iPSCs and lung stem cells.
The Stem Cellar 