Dr. Xinnan Wang, a neurosurgeon and author of a study that has identified a molecular pathway apparently responsible for the death of dopaminergic neurons that causes the symptoms of Parkinson's. Of the various neurodegenerative diseases, Parkinson's is the second most common and affects 35 million people world wide. It is caused by the gradual breakdown of … Continue reading CIRM-funded Stanford study finds potential diagnostic tool, treatment for Parkinson’s
neurons
Genetic defect leads to slower production of brain cells linked to one form of autism
Child with Fragile X syndrome Fragile X syndrome (FXS) is a genetic disorder that is the most common form of inherited intellectual disability in children, and has also been linked to a form of autism. Uncovering the cause of FXS could help lead to a deeper understanding of autism, what causes it and ultimately, it’s … Continue reading Genetic defect leads to slower production of brain cells linked to one form of autism
Stem cell model reveals deeper understanding into ALS resilient neurons
A descriptive illustration of Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's Disease. Courtesy of ALS Foundation website. Understanding the basic biology of how a cell functions can be crucial to better understanding a disease and unlocking a potential treatment approach. Stem cells are unique because they let scientists create a controlled cell environment … Continue reading Stem cell model reveals deeper understanding into ALS resilient neurons
A new stem cell derived tool for studying brain diseases
Sergiu Pasca’s three-dimensional culture makes it possible to watch how three different brain-cell types – oligodendrocytes (green), neurons (magenta) and astrocytes (blue) – interact in a dish as they do in a developing human brain. Courtesy of the Pasca lab Neurological diseases are among the most daunting diagnoses for a patient to receive, because they … Continue reading A new stem cell derived tool for studying brain diseases
Using 3D printer to develop treatment for spinal cord injury
Spinal cord injuries (SCIs) affect approximately 300,000 Americans, with about 18,000 new cases occurring per year. One of these patients, Jake Javier, who we have written about many times over the past several years, received ten million stem cells as part of a CIRM-funded clinical trial and a video about his first year at Cal … Continue reading Using 3D printer to develop treatment for spinal cord injury
CIRM-funded research is helping unlock the secrets behind “chemo brain”
Every year millions of Americans undergo chemotherapy. The goal of the treatment is to destroy cancer, but along the way more than half of the people treated lose something else. They suffer from something called “chemo brain” which causes problems with thinking and memory. In some cases it can be temporary, lasting a few months. … Continue reading CIRM-funded research is helping unlock the secrets behind “chemo brain”
Japanese scientists implant first Parkinson’s patient with replacement neurons derived from stem cells
Currently, more than 10 million people worldwide live with Parkinson’s disease (PD). By 2020, in the US alone, people living with Parkinson’s are expected to outnumber the cases of multiple sclerosis, muscular dystrophy and Lou Gehrig’s disease combined. There is no cure for Parkinson’s and treatment options consist of medications that patients ultimately develop tolerance … Continue reading Japanese scientists implant first Parkinson’s patient with replacement neurons derived from stem cells
Why having a wrinkled brain is a good thing
We normally associate wrinkles with aging, such as wrinkled skin. But there’s one organ that is wrinkled right from the time we are born. It's complex Those wrinkles are part of the brain. New research shows they signal how large and complex our brains are. According to UCSB postdoctoral scholar Eyal Karzbrun, the folds increase … Continue reading Why having a wrinkled brain is a good thing
Using biological “codes” to generate neurons in a dish
Investigators at the Scripps Research Institute are making brain waves in the field of neuroscience. Until now, neuroscience research has largely relied on a variety of animal models to understand the complexities of various brain or neuronal diseases. While beneficial for many reasons, animal models do not always allow scientists to understand the precise mechanism … Continue reading Using biological “codes” to generate neurons in a dish
CIRM Board Approves $16.4 million for Early Stage Discovery Research
David Higgins, CIRM Board member and Patient Advocate for Parkinson's disease; Photo courtesy San Diego Union Tribune The California Institute for Regenerative Medicine (CIRM) board approved $16 million for more than a dozen Discovery‑stage research programs. These projects span Parkinson’s disease, new drug targets for cancer stem cells, and methods for creating human airway stem … Continue reading CIRM Board Approves $16.4 million for Early Stage Discovery Research