Image Credit: The Adler Lab at the University of California, San Diego In the fall of 2024, the California Institute for Regenerative Medicine (CIRM) helped sponsor the Gene Therapy Initiative symposium in La Jolla, CA. While there, CIRM staff caught up with a few CIRM grantees who are working on gene therapy approaches to treating … Continue reading Gene Therapy for Heart Failure: A Conversation with Eric Adler, MD
Heart Disease/Stroke
Advancing Heart Health: CIRM Funds Tenaya Therapeutics’ Gene Therapy Trial for ARVC
Histology of human cardiac muscle under microscope. Credit: Shutterstock The California Institute for Regenerative Medicine (CIRM) recently announced funding a series of projects spanning the earliest stages of research through to clinical trials. One of those projects was an $8 million award to Matthew Pollman, MD, MS, Senior Vice President of Clinical Development at Tenaya … Continue reading Advancing Heart Health: CIRM Funds Tenaya Therapeutics’ Gene Therapy Trial for ARVC
UCLA researchers exploring ways to prevent heart failure after heart attacks
ENPP1 is expressed in the region of scarring after injury to the heart. Cardiac muscle shown in red and ENPP1 in green demonstrates expression of ENPP1 in the region of scar formation. | Credit: Arjun Deb Lab/UCLA At the California Institute for Regenerative Medicine (CIRM), we support groundbreaking cardiovascular research from Discovery to Clinical as … Continue reading UCLA researchers exploring ways to prevent heart failure after heart attacks
CIRM $4 million awarded to support innovative Gene Therapy for Rare Heart Disorder
Image Source: American Heart Association Journals The California Institute for Regenerative Medicine (CIRM) recently awarded $4 million to support the development of a one-time gene therapy for desmoplakin gene variant arrhythmogenic cardiomyopathy (DSP ACM), a rare and life-threatening genetic disorder. This preclinical award to Deborah D. Ascheim, MD, and her team at Rejuvenate Bio are … Continue reading CIRM $4 million awarded to support innovative Gene Therapy for Rare Heart Disorder
CIRM awards $26 million to boost clinical trials for cancer, heart, and rare diseases
The California Institute for Regenerative Medicine (CIRM) is proud to announce the allocation of $26 million to support clinical research targeting a range of cancers, heart conditions, and rare diseases. This significant funding underscores CIRM’s commitment to advancing innovative stem cell and gene therapy-based treatments through all stages of clinical trial development. This latest round … Continue reading CIRM awards $26 million to boost clinical trials for cancer, heart, and rare diseases
CIRM awards $6 million to advance research for heart attack and heart failure treatments
In a promising development for cardiovascular health, Arjun Deb, MD, a professor of medicine and molecular, cell, and developmental biology at UCLA, has received a $6 million award from the California Institute for Regenerative Medicine (CIRM) to advance his groundbreaking research on heart attack and heart failure treatments. Cardiovascular disease remains the leading cause of … Continue reading CIRM awards $6 million to advance research for heart attack and heart failure treatments
Myocarditis in Cancer Patients Is Driven by Specific Immune Cells
In a new study, researchers from UC San Francisco and Vanderbilt University Medical Center have identified specific immune cells that cause a potentially lethal heart inflammation -called myocarditis- in a small fraction of patients treated with powerful cancer immunotherapy drugs. Myocarditis is inflammation of the heart muscle. It can cause chest pain, shortness of breath, … Continue reading Myocarditis in Cancer Patients Is Driven by Specific Immune Cells
Fighting for his life and the lives of other stroke survivors
Sean Entin, stroke survivor and founder of Stroke Hacker The word "miraculous" gets tossed around a lot in the world of medicine, mostly by people who have made an unexpected recovery from a deadly or life-threatening condition. In Sean Entin's case calling his recovery from an almost-fatal stroke could be called miraculous, but I think … Continue reading Fighting for his life and the lives of other stroke survivors
Using stem cells and smart machines to warn of heart problems
Despite advances in treatments in recent years heart disease remains the leading cause of death in the US. It accounts for one in three deaths in this country, and many people are not even aware they have a problem until they have a heart attack. One of the early warning signs of danger is a … Continue reading Using stem cells and smart machines to warn of heart problems
Stem Cell Agency Board Invests in 19 Discovery Research Programs Targeting Cancers, Heart Disease and Other Disorders
THIS BLOG IS ALSO AVAILABLE AS AN AUDIO CAST Dr. Judy Shizuru, Stanford University While stem cell and gene therapy research has advanced dramatically in recent years, there are still many unknowns and many questions remaining about how best to use these approaches in developing therapies. That’s why the governing Board of the California Institute … Continue reading Stem Cell Agency Board Invests in 19 Discovery Research Programs Targeting Cancers, Heart Disease and Other Disorders
The Stem Cellar 