In these uncertain times, we often look to our top scientists for answers as well as potential solutions. But where does one begin to try and solve a problem of this magnitude? The first logical step is building on the supplies currently available, the work already accomplished, and the knowledge acquired. This is the approach … Continue reading Gladstone scientists respond to coronavirus pandemic
Author: Yimy Villa
A recap on last week: two gut wrenching studies
Fluorescent pictures of a human colon organoidImage credit: Dr Thierry Jarde With everyone stocking up on food essentials this past week, it brings to mind the vital role that our stomach plays in order to properly digest these foods. This week, we wanted to share two separate studies related to aspects of the gut. Promising … Continue reading A recap on last week: two gut wrenching studies
New hydrogel developed could aid in therapies to generate bones in head and neck
Taking a cue from mussels' natural ability to adhere to surfaces underwater, the UCLA researchers incorporated an alginate-based solution in their hydrogel.Photo taken by D. Jude, Univ. of Michigan When most people think of mussels, what immediately comes to mind might be a savory seafood dish or favorite seafood restaurant. But to Dr. Alireza Moshaverinia … Continue reading New hydrogel developed could aid in therapies to generate bones in head and neck
CIRM-funded trial for blood cancer releases promising new data
A CIRM-funded trial conducted by Oncternal Therapeutics in collaboration with UC San Diego released an interim clinical data update for patients with mantle cell lymphoma (MCL), a type of blood cancer. The treatment being developed involves an antibody called cirmtuzumab (named after yours truly) being used with a cancer fighting drug called ibrutinib. The antibody … Continue reading CIRM-funded trial for blood cancer releases promising new data
CIRM-funded treatment for Cystinosis receives orphan drug designation
Dr. Stephanie Cherqui, UC San Diego Orphan drug designation is a special status given by the Food and Drug Administration (FDA) for potential treatments of rare diseases that affect fewer than 200,000 in the U.S. This type of status can significantly help advance treatments for rare diseases by providing financial incentives in the form of … Continue reading CIRM-funded treatment for Cystinosis receives orphan drug designation
New CAR-T cell therapy using scorpion venom developed to treat brain tumors
Contributed by Wikimedia Commons (Public Domain) Glioblastoma (GBM) is an aggressive form of cancer that begins in the brain and results in tumors that can be very difficult to treat. This condition has claimed the lives of Beau Biden, former Vice President Joe Biden's son, and John McCain, former Senator of Arizona. However, a new … Continue reading New CAR-T cell therapy using scorpion venom developed to treat brain tumors
Stem cell transplant in utero offers potential treatment for congenital diseases
Dr. Tippi Mackenzie, UCSFImage Credit: UCSF Each year, around 24,000 women in the US lose a pregnancy. One reason for this unfortunate occurrence are metabolic disorders, one of which is known as Sly syndrome and is caused by a single genetic mutation. In Sly syndrome, the body's cells lack an enzyme necessary for proper cell … Continue reading Stem cell transplant in utero offers potential treatment for congenital diseases
Overcoming obstacles in blood stem cell therapies
Photo Credit: OHSU Knight Cancer Institute Today, we here at CIRM wanted to provide an update on the fascinating world of hematopoietic (blood) stem cell-based therapies. What is the current status of this promising field and what are some of the challenges that need to be overcome? Dr. Kelly Shepard, Associate Director of Discovery and … Continue reading Overcoming obstacles in blood stem cell therapies
CIRM supported study finds that a gene associated with autism influences brain stem cells
Dr. Bennett Novitch, UCLA Broad Stem Cell Research CenterImage Credit: UCLA Broad Stem Cell Research Center In a previous blog post, we discussed new findings in a CIRM supported study at the Salk Institute for Autism Spectrum Disorder (ASD), a developmental disorder that comes in broad ranges and primarily affects communication and behavior. This week, … Continue reading CIRM supported study finds that a gene associated with autism influences brain stem cells
CIRM funded study links rapid brain growth in autism to DNA damage
Meiyan Wang and Dr. Rusty Gage at the Salk Institute. Image Credit: Salk Institute Autism spectrum disorder (ASD), is a developmental disorder that comes in broad ranges and primarily affects communication and behavior. Many people with ASD also have macrocephaly, or unusually large heads. Unfortunately, understanding the underlying causes of this disorder and development of … Continue reading CIRM funded study links rapid brain growth in autism to DNA damage
The Stem Cellar 