A new study published in the journal Cell Stem Cell, reveals how different types of cells in the bone marrow are responsible for supporting blood stem cell maintenance before and after injury. It was already well known in the field that two different cell types, namely endothelial cells (which line blood vessels) and stromal cells … Continue reading Support cells have different roles in blood stem cell maintenance before and after stress
Author: Pallavi Penumetcha
For the first time, scientists entirely reprogram human skin cells to iPSCs using CRISPR
Back in 2012, Shinya Yamanaka was awarded the Nobel Prize in Physiology or Medicine for his group’s identification of “Yamanaka Factors,” a group of genes that are capable of turning ordinary skin cells into induced pluripotentent stem cells (iPSCs) which have the ability to become any type of cell within the body. Discovery of iPSCs … Continue reading For the first time, scientists entirely reprogram human skin cells to iPSCs using CRISPR
“Junk” DNA is development gold for the dividing embryo
The DNA in our cells provide the instructions to make proteins, the workhorses of our body. Yet less than 2% of the 3 billion base pairs (the structural units of DNA) in each of our cells are actually involved in protein production. The rest, termed non-coding DNA for not being involved in protein production, has … Continue reading “Junk” DNA is development gold for the dividing embryo
Timing is a critical factor in kidney development
Through countless studies, it's clear that genes and environmental factors are important for determining cellular identity. Now, a research team at the University of Southern California (USC) have found that timing is another critical factor in determining cell fate during organ development. In findings published in Development Cell, Dr. Andy McMahon’s group shows that development … Continue reading Timing is a critical factor in kidney development
CIRM funded study results in the first ever in utero stem cell transplant to treat alpha thalassemia
Imagine being able to cure a genetic disorder before a baby is even born. Thanks to a CIRM funded study, what would have been a mere dream a couple of years ago has become a reality. Drs. Tippi MacKenzie and Juan Gonzalez Velez of the University of California San Francisco (UCSF) have successfully treated alpha … Continue reading CIRM funded study results in the first ever in utero stem cell transplant to treat alpha thalassemia
Making stem cell-derived liver cells to study fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects approximately 30% of the population, with that number increasing to 75% in obese individuals. Shockingly, the number of cases is expected to increase 21% by the year 2030 in the United States alone. NAFLD refers to a broad range of liver conditions, which are all characterized by abnormally high … Continue reading Making stem cell-derived liver cells to study fatty liver disease
New findings about muscle stem cells reveals the potential for growing replacement organs
Chrissa Kioussi’s group at Oregon State University has made exciting advances in further unraveling the scientific mysteries of stem cells. In work detailed in Scientific Reports, this group found that muscle-specific stem cells actually have the ability to make multiple different cell types. Initially, this group was interested in understanding how gene expression changes during … Continue reading New findings about muscle stem cells reveals the potential for growing replacement organs
Using biological “codes” to generate neurons in a dish
Investigators at the Scripps Research Institute are making brain waves in the field of neuroscience. Until now, neuroscience research has largely relied on a variety of animal models to understand the complexities of various brain or neuronal diseases. While beneficial for many reasons, animal models do not always allow scientists to understand the precise mechanism … Continue reading Using biological “codes” to generate neurons in a dish
Coming up with a stem cell FIX for a life-threatening blood disorder
A promising new treatment option for hemophiliacs is in the works at the Salk Institute for Biological Sciences. Patients with Hemophilia B experience uncontrolled, and sometimes life threatening, bleeding due to loss or improper function of Factor IX (FIX), a protein involved in blood clotting. There is no cure for the disease and patients rely … Continue reading Coming up with a stem cell FIX for a life-threatening blood disorder
The Stem Cellar 