How to handle CRISPR: Formulating a responsible approach to gene-editing

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In February 2016, CIRM sponsored a workshop to discuss the impact of CRISPR, a gene-editing tool that is transforming stem cell research. The workshop was designed to enable the Standards Working Group  (SWG) to reflect on policies governing the review and oversight of embryo research support by CIRM.

After the workshop, we wrote a blog about some of the important questions that came up during the discussion. There is also a written and audio transcript of the meeting here.

Since then, the CIRM Team has been working with the co-chairs of the Standards Working Group to develop draft recommendations for how CIRM could address the workshop questions. The draft recommendations may be found here.

As we noted in June 2015, these deliberations and subsequent recommendations are designed to inform the responsible uses of genome editing technologies with CIRM funds. In particular, CIRM continues to place a priority on funding research that does not receive timely or sufficient federal funding – for example research involving human embryos.

As was discussed at the workshop, donors indicated strong support for embryo research for:

  1. Understanding human development and
  2. Creating stem cell lines.

Genome editing may be applied to both types of research.

The draft recommendations are intended to ensure such work may occur under high ethical standards. After the Standards Working Group review, the final recommendations will be forwarded to CIRM’s governing Board, the ICOC, for approval. We hope that will happen this summer.

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