THIS BLOG IS ALSO AVAILABLE AS AN AUDIO CAST Researchers use mRNA to introduce the gene editor CRISPR-Cas9 into human muscle stem cells. These cells fused into multinucleated myotubes following mRNA-mediated CRISPR-Cas9 gene editing. A myosin heavy chain is seen in green and the nuclei in blue. Photo: Spuler Lab A team of researchers from … Continue reading How mRNA and CRISPR-Cas9 could treat muscle atrophy
Muscles
Muscle stem cells provide insight into treatment of muscular dystrophies and aging muscles
Dr. Alessandra Sacco, associate professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys. Muscles are a vital part of the body that enable us to walk, run, lift, and do everyday activities. When muscles start to deteriorate, we start to have difficulty performing these activities, which severely limits quality of life and … Continue reading Muscle stem cells provide insight into treatment of muscular dystrophies and aging muscles
Gene editing treats mice with Duchenne muscular dystrophy
On New Year's Eve, Science magazine published three articles (here, here, here) simultaneously that successfully used CRISPR/Cas9 gene editing to treat mice that have Duchenne muscular dystrophy (DMD). DMD is a rare, genetic disease that affects approximately 1 in 3,600 boys in the US. It’s caused by a mutation in the dystrophin gene, which generates … Continue reading Gene editing treats mice with Duchenne muscular dystrophy
Using satellites to build bigger biceps
There are several ways you can build bigger, stronger muscles. You can take the approach favored by our former Governor, Arnold Schwarzenegger, and pump iron till your biceps are as inflated as a birthday balloon. Or you could follow the lead of a research team we are funding and try to use stem cells to … Continue reading Using satellites to build bigger biceps
Researchers cool to idea of ice bath after exercise
Have you ever had a great workout, really pushed your body and muscles hard and thought “You know what would be good right now? A nice plunge into an ice bath.” No. Me neither. But some people apparently believe that taking an ice bath after a hard workout can help their muscles rebound and get … Continue reading Researchers cool to idea of ice bath after exercise