There are limitations to studying cells under a microscope. To understand some of the more complex processes, it is critical to see how these cells behave in an environment that is similar to conditions in the body. The production of organoids has revolutionized this approach. Organoids are three-dimensional structures derived from stem cells that have … Continue reading Organoids revolutionize approach to studying a variety of diseases
Stem Cell Image of the Week: Obesity-in-a-dish reveals mutations and abnormal function in nerve cells Our stem cell image of the week looks like the work of a pre-historic cave dweller who got their hands on some DayGlo paint. But, in fact, it’s a fluorescence microscopy image of stem cell-derived brain cells from the lab … Continue reading Stem Cell Roundup: The brain & obesity; iPSCs & sex chromosomes; modeling mental illness
Can you guess what the tiny white balls are in this photo? I’ll give you a hint, they represent the organ that you’re using right now to answer my question. These are 3D brain organoids generated from human pluripotent stem cells growing in a culture dish. You can think of them as miniature models of … Continue reading Modeling the Human Brain in 3D
New human Mini-brain model of devastating childhood disease. The eradication of Aicardi-Goutieres Syndrome (AGS) can’t come soon enough. This rare but terrible inherited disease causes the immune system to attack the brain. The condition leads to microcephaly (an abnormal small head and brain size), muscle spasms, vision problems and joint stiffness during infancy. Death or … Continue reading CIRM weekly stem cell roundup: minibrain model of childhood disease; new immune insights; patient throws out 1st pitch
This week we bring you three separate stories about the brain. Two are exciting new advances that use stem cells to understand the brain and the third is plain creepy. Bioengineering better brains. Lab grown mini-brains got an upgrade thanks to a study published this week in Nature Biotechnology. Mini-brains are tiny 3D organs that … Continue reading Stem cell stories that caught our eye: brains, brains and more brains!
April is National Autism Awareness Month and people and organizations around the world are raising awareness about a disorder that affects more than 20 million people globally. Autism affects early brain development and causes a wide spectrum of social, mental, physical and emotional symptoms that appear during childhood. Because the symptoms and their severity can … Continue reading One scientist’s quest to understand autism using stem cells
From January 8th to 13th, nearly 300 scientists and trainees from around the world ascended the mountains near Lake Tahoe to attend the joint Keystone Symposia on Neurogenesis and Stem Cells at the Resort at Squaw Creek. With record-high snowfall in the area (almost five feet!), attendees had to stay inside to stay warm and dry, … Continue reading Avalanches of exciting new stem cell research at the Keystone Symposia near Lake Tahoe
For the fourth entry for our “Ten Years of Induced Pluripotent Stem (iPS) Cells” series, which we’ve been posting all month, I reached out to three of our CIRM grantees to get their perspectives on the impact of iPSC technology on their research and the regenerative medicine field as a whole: Step back in time … Continue reading CIRM Grantees Reflect on Ten Years of iPS Cells
Here are some stem cell stories that caught our eye this past week. Some are groundbreaking science, others are of personal interest to us, and still others are just fun. Mimicking human air sacs – a new lab tool for studying respiratory disease Studying a flat lawn of cells in a petri dish is so … Continue reading Stem cell stories that caught our eye: 3D mini-lungs, Parkinson’s culprit, Motherless babies!
Here are some stem cell stories that caught our eye this past week. Some are groundbreaking science, others are of personal interest to us, and still others are just fun. Stem cells may be option in glaucoma. A few (potentially) blind mice did not run fast enough in an Iowa lab. But lucky for them … Continue reading Stem cell stories that caught our eye: potential glaucoma therapy, Parkinson’s model, clinical trial list, cancer immune therapy