Wiping out a cell’s identity shifts cellular reprogramming into high gear

If stretched out end to end, the DNA in just one cell of your body would reach a whopping six feet in length. A complex cellular structure called chromatin – made up of coils upon coils of DNA and protein – makes it possible to fit all that DNA into a single cell nucleus that’s … Continue reading Wiping out a cell’s identity shifts cellular reprogramming into high gear

A Win for Diabetes: Scientists Make Functional Pancreatic Cells From Skin

Today is an exciting day for diabetes research and patients. For the first time, scientists have succeeded in making functional pancreatic beta cells from human skin. This new method for making the insulin-producing cells of the pancreas could produce a new, more effective treatment for patients suffering from diabetes. Researchers at the Gladstone Institutes and … Continue reading A Win for Diabetes: Scientists Make Functional Pancreatic Cells From Skin

Stem cell stories that caught our eye: fighting cancer, a cell’s neighborhood matters, funding next generation scientists

Here are some stem cell stories that caught our eye this past week. Some are groundbreaking science, others are of personal interest to us, and still others are just fun. Reprogramming skin to fight cancer. Earlier CIRM-funded research showed that adult nerve stem cells can home to the residual brain cancer left behind after surgery … Continue reading Stem cell stories that caught our eye: fighting cancer, a cell’s neighborhood matters, funding next generation scientists

Computer “Magic” Helps Scientists Morph One Cell’s Identity Into Another

Mogrify. Sounds like one of Harry Potter’s spells, doesn’t it? In reality, it’s something cooler than that. As reported on Tuesday in Nature Genetics, Mogrify is a new research tool that uses the magic of mathematics and computer programming to help stem cell scientists determine the necessary ingredients to convert one human cell type into … Continue reading Computer “Magic” Helps Scientists Morph One Cell’s Identity Into Another

Stem cell stories that caught our eye: three teams refine cell reprogramming, also stem cell tourism

Here are some stem cell stories that caught our eye this past week. Some are groundbreaking science, others are of personal interest to us, and still others are just fun. Why stem cells in the lab don’t grow up right. A classic cartoon among stem cell fans shows a stem cell telling a daughter cell … Continue reading Stem cell stories that caught our eye: three teams refine cell reprogramming, also stem cell tourism

CIRM-Funded Scripps Team Replicates Pain in a Lab Dish; Seeks New Treatments for Chronic Sufferers

Pain hurts but it also protects. Thanks to nerve cells called sensory neurons, which weave their nerve fibers throughout our skin and other tissues, we are alerted to dangerous events like touching a hot plate or even to the sense of having a full bladder. However, trauma such as a spinal cord injury or diseases … Continue reading CIRM-Funded Scripps Team Replicates Pain in a Lab Dish; Seeks New Treatments for Chronic Sufferers

Scar-forming cells in the heart converted directly into beating heart muscle

Last year, our grantees at Gladstone Institutes worked a neat trick: they converted the scar-forming cells of the heart directly into beating heart cells in living mice. (We wrote about that work here.) The cells they converted, also called fibroblasts, are the ones that create scar tissue in the heart after a heart attack. Their … Continue reading Scar-forming cells in the heart converted directly into beating heart muscle

A cardiac regenerative medicine update from the World Stem Cell Summit

Ben Paylor originally posted this entry about cardiac regenerative medicine results being discussed at the World Stem Cell Summit on the Canadian Stem Cell Network’s Signals blog. Just over two years ago I wrote about early reports from Dr. Roberto Bolli et al.’s SCIPIO trial running out of the University of Louisville in collaboration with … Continue reading A cardiac regenerative medicine update from the World Stem Cell Summit

Smithsonian discusses new stem cells discovered by CIRM grantee Thea Tlsty

Virginia Hughes wrote for the July-August issue of Smithsonian about the recent work by our grantee Thea Tlsty, who discovered cells in the adult body that can form all tissue types. (We wrote about that work here.) All previously identified stem cells in adult tissues could only go on to form the cell types found … Continue reading Smithsonian discusses new stem cells discovered by CIRM grantee Thea Tlsty