City of Hope scientists use stem cells to develop ‘mini-brains’ to study Alzheimer’s and to test drugs in development

Alzheimer’s is a progressive disease that destroys memory and other important mental functions. According to the non-profit HFC, co-founded by CIRM Board member Lauren Miller Rogen and her husband Seth Rogen, more than 5 million Americans are living with Alzheimer’s. It is the 6th leading cause of death in the U.S and it is estimated … Continue reading City of Hope scientists use stem cells to develop ‘mini-brains’ to study Alzheimer’s and to test drugs in development

Scientists use stem cell ‘mini-brains’ to better understand signs of frontotemporal dementia

Dementia is a general term that describes a set of diseases that impair the ability to remember, think, or make decisions that interfere with doing everyday activities. According to the World Health Organization (WHO), around 50 million people worldwide have dementia with nearly 10 million new cases every year. Although it primarily affects older people … Continue reading Scientists use stem cell ‘mini-brains’ to better understand signs of frontotemporal dementia

Scientists use stem cells to create Neanderthal-like “mini-brain”

The evolution of modern day humans has always been a topic that has been shrouded in mystery. Some of what is known is that Neanderthals, an archaic human species that lived on this planet up until about 11,700 years ago, interbred with our species (Homo sapiens) at some point in time. Although their brains were … Continue reading Scientists use stem cells to create Neanderthal-like “mini-brain”

“Mini-brains” model an autism spectrum disorder and help test treatments

Rett syndrome is a rare form of autism spectrum disorder that impairs brain development and causes problems with movement, speech, and even breathing. It is caused by mutations in a gene called MECP2 and primarily affects females. Although there are therapies to alleviate symptoms, there is currently no cure for this genetic disorder. With CIRM … Continue reading “Mini-brains” model an autism spectrum disorder and help test treatments

Adding the missing piece: “mini-brain” method now includes important cell type

Although studying brain cells as a single layer in petri dishes has led to countless ground-breaking discoveries in neurobiology, it’s pretty intuitive that a two-dimensional “lawn” of cells doesn’t fully represent what’s happening in our complex, three-dimensional brain. In the past few years, researchers have really upped their game with the development of brain organoids, … Continue reading Adding the missing piece: “mini-brain” method now includes important cell type

UC Davis researchers make stem cell-derived mini-brains that contain blood vessels

Growing neurons on a flat petri dish is a great way to study the inner workings of nerve signals in the brain. But I think it’s safe to argue that a two-dimensional lawn of cells doesn’t capture all the complexity of our intricate, cauliflower-shaped brains. Then again, cracking open the skulls of living patients is … Continue reading UC Davis researchers make stem cell-derived mini-brains that contain blood vessels

Stem Cell Stories that Caught our Eye: Mini-Brains in the Spotlight

Here are the stem cell stories that caught our eye this week. Two research photos really caught my eye this week and they happened to be of the same thing – mini-brains. Also referred to as brain organoids, mini-brains are tiny balls of nervous tissue grown from stem cells in the lab. They allow scientists … Continue reading Stem Cell Stories that Caught our Eye: Mini-Brains in the Spotlight

Caught our eye: new Americans 4 Cures video, better mini-brains reveal Zika insights and iPSC recipes go head-to-head

How stem cell research gives patients hope (Karen Ring). You can learn about the latest stem cell research for a given disease in seconds with a quick google search. You’ll find countless publications, news releases and blogs detailing the latest advancements that are bringing scientists and clinicians closer to understanding why diseases happen and how … Continue reading Caught our eye: new Americans 4 Cures video, better mini-brains reveal Zika insights and iPSC recipes go head-to-head

Brain Models Get an Upgrade: 3D Mini-Brains

Every year, companies like Apple, Microsoft and Google work tirelessly to upgrade their computer, software and smartphone technologies to satisfy growing demands for more functionality. Much like these companies, biomedical scientists work tirelessly to improve the research techniques and models they use to understand and treat human disease. Today, I’ll be talking about a cool … Continue reading Brain Models Get an Upgrade: 3D Mini-Brains

Stem cell stories that caught our eye: mini-brains in a dish, blood stem cells and state funded stem cell research

Here are some stem cell stories that caught our eye this past week. Some are groundbreaking science, others are of personal interest to us, and still others are just fun. Great review of brains in a dish. The veteran Associated Press science journalist Malcolm Ritter produced the most thorough overview I have seen of the … Continue reading Stem cell stories that caught our eye: mini-brains in a dish, blood stem cells and state funded stem cell research