CIRM Board invests in new approaches to brain cancer and Parkinson’s disease

Parkinson’s disease and glioblastoma are very different diseases of the brain but neither has very good treatment options and both clearly represent an unmet medical need. With that in mind, the governing Board of the California Institute for Regenerative Medicine (CIRM), the state’s stem cell agency, yesterday voted to invest almost $9.5 million in developing … Continue reading CIRM Board invests in new approaches to brain cancer and Parkinson’s disease

Novel approach to slowing deadly brain cancer stem cells may lead to new treatments

Glioblastoma, a form of brain cancer, is one of the most dreaded cancer diagnoses. Standard radiation and chemotherapy treatments for glioblastoma almost always prove ineffective because of the cancer’s ability to grow back. With their unlimited potential to self-renew, cancer stem cells within the brain tumor are thought to be responsible for its aggressive reoccurrence. … Continue reading Novel approach to slowing deadly brain cancer stem cells may lead to new treatments

Taking a new approach to fighting a deadly brain cancer

CIRM’s 2017 Annual Report will be going live online very soon. In anticipation of that we are highlighting some of the key elements from the report here on the Stem Cellar. One of the most exciting new approaches in targeting deadly cancers is chimeric antigen receptor (CAR) T-cell therapy, using the patient’s own immune system … Continue reading Taking a new approach to fighting a deadly brain cancer

Stem Cell Stories That Caught Our Eye: Halting Brain Cancer, Parkinson’s disease and Stem Cell Awareness Day

Stopping brain cancer in its tracks. Scientists at Stanford Medicine discovered that you can halt aggressive brain cancers called high-grade gliomas by cutting off their supply of a signaling protein called neuroligin-3. Their research, which was funded by CIRM and the NIH, was published this week in the journal Nature.  The Stanford team, led by … Continue reading Stem Cell Stories That Caught Our Eye: Halting Brain Cancer, Parkinson’s disease and Stem Cell Awareness Day

Stem cell stories that caught our eye: Horse patients, Brain cancer stem cells, and a Bony Heart

Horsing around at the World Stem Cell Summit The World Stem Cell Summit (WSCS) is coming up very shortly (December 6-9) in lovely downtown West Palm Beach, Florida. And this year it has an added attraction; horses. For my money the WSCS is the most enjoyable of the many conferences held around the US focusing … Continue reading Stem cell stories that caught our eye: Horse patients, Brain cancer stem cells, and a Bony Heart

Achilles’ Heel of Brain Cancer Identified in Tumor Stem Cells

Few words strike me with more dread than glioblastoma, the name for a very aggressive, incurable cancer of the brain. Although surgery and chemotherapy can help hold off or reverse a glioblastoma’s growth for a while, almost inevitably the tumor comes back along with a terrible prognosis: an average survival time of 12 to 15 … Continue reading Achilles’ Heel of Brain Cancer Identified in Tumor Stem Cells

Scientists use human stem cell models to target deadly brain cancer

Malignant brain cancer is a devastating disease and it’s estimated that more than 16,000 patients will die of it this year. One of the most aggressive forms of brain cancer is gliomas, which originate from the support cells in the brain or spine that keep nerve cells happy and functioning. Unfortunately, there is no cure … Continue reading Scientists use human stem cell models to target deadly brain cancer

Two studies show genes and their switches critical to brain cancer’s resistance to therapy

Two California teams discovered genetic machinery that cancer stem cells in high-grade brain cancers use to evade therapy. One CIRM-funded team at Cedars-Sinai in Los Angeles pinpointed a family of genes that turn off other genes that chemotherapy targets —effectively hiding them from the chemo. The other team at the University of California, San Diego … Continue reading Two studies show genes and their switches critical to brain cancer’s resistance to therapy

Stem cell stories that caught our eye: Lou Gehrig’s disease, misbehaving cells, and nanotech for brain cancer

Here are some stem cell stories that caught our eye this past week. Some are groundbreaking science, others are of personal interest to us, and still others are just fun.  Clinical trial in Lou Gehrig’s disease moves to Phase 2. It is always rewarding when you read about clinical trials in our field advancing. This … Continue reading Stem cell stories that caught our eye: Lou Gehrig’s disease, misbehaving cells, and nanotech for brain cancer

CIRM Board Approves New Clinical Trial for Breast Cancer Related Brain Metastases

Yesterday the governing Board of the California Institute for Regenerative Medicine (CIRM) awarded $9.28 million to Dr. Saul Priceman at City of Hope to conduct a clinical trial for the treatment of breast cancer related brain metastases, which are tumors in the brain that have spread from the original site of the breast cancer. This … Continue reading CIRM Board Approves New Clinical Trial for Breast Cancer Related Brain Metastases